Ignite Creation Date:
2024-06-16 @ 11:50 AM
Last Modification Date:
2024-10-26 @ 3:31 PM
Study NCT ID:
NCT06444646
Status:
RECRUITING
Last Update Posted:
2024-06-05
First Post:
2023-02-27
Brief Title:
Differences in Extracellular Vesicles From Adipose Tissue of Individuals With Obesity
Sponsor:
Hasselt University
Organization:
Hasselt University
Study Overview
Official Title:
The Adipose Tissue and Sex-specific Role of Adipose-derived Extracellular Vesicles in Obesity-related Skeletal Muscle Insulin Resistance
Status:
RECRUITING
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
EVO
Brief Summary:
Our society is characterized by a strong increase in the prevalence of obesity which often causes the development of cardiovascular and metabolic diseases such as type 2 diabetes The ways obesity is responsible for these diseases is still insufficiently understood This study therefore examines the content of human fat tissue storage location- and cell type-specific extracellular vesicles EVs in lean and obese individuals and the possible connection with sex insulin sensitivity and the blood-brain barrier
Detailed Description:
This study focuses on unraveling the fundamental differences in communication via extracellular vesicles EVs derived from fat cells and immune cells in terms of fat tissue storage location and sex among individuals with and without obesity The study hypothesizes that the differences in EV profiles originating from corresponding in vitro differentiated hMADS and ex vivo isolated adult fat cells and immune cells among individuals with and without obesity can be related to sex andor fat tissue storage location Additionally the effect of the isolated EVs on the blood-brain barrier function is also investigated
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None