Ignite Creation Date:
2024-05-05 @ 9:57 AM
Last Modification Date:
2024-10-26 @ 9:02 AM
Study NCT ID:
NCT00001889
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
1999-11-03
Brief Title:
Comparison of Echocardiographic Techniques in Diagnosis of Coronary Artery Disease
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Comparison of Myocardial Contrast Echo With Dobutamine Echo in Diagnosis of Coronary Artery Disease
Status:
COMPLETED
Status Verified Date:
2000-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study is designed to compare two different echocardiographic techniques in the evaluation of heart disease coronary artery disease Both tests called Myocardial Contrast Echocardiography with Pharmacologic Stress and Stress Echocardiography with Dobutamine are performed using a standard echocardiographic machine
Myocardial Contrast Echocardiography MCE does not use radioactivity It uses sound waves like standard echocardiography However with MCE patients receive an injection of a contrast agent directly into the blood stream through a vein The contrast agent called Optison is made of tiny microbubbles smaller than red blood cells The echocardiogram can detect these microbubbles in the small blood vessels of the heart muscle and allow researchers to find areas of the heart receiving less blood flow than others It is important to observe the heart during exercise because there are changes in blood flow Since MCE cannot be performed when the patient is exercising researchers give medication adenosine that stimulates the heart and creates a situation similar to exercise
Stress Echocardiography with Dobutamine does not use radioactivity It uses sound waves like standard echocardiography During this echocardiogram patients receive doses of a medication called dobutamine that stimulates the heart to beat stronger and faster
The purpose of this study is to evaluate the accuracy of MCE compared to stress echocardiography at detecting coronary artery disease CAD
Myocardial Contrast Echocardiography MCE does not use radioactivity It uses sound waves like standard echocardiography However with MCE patients receive an injection of a contrast agent directly into the blood stream through a vein The contrast agent called Optison is made of tiny microbubbles smaller than red blood cells The echocardiogram can detect these microbubbles in the small blood vessels of the heart muscle and allow researchers to find areas of the heart receiving less blood flow than others It is important to observe the heart during exercise because there are changes in blood flow Since MCE cannot be performed when the patient is exercising researchers give medication adenosine that stimulates the heart and creates a situation similar to exercise
Stress Echocardiography with Dobutamine does not use radioactivity It uses sound waves like standard echocardiography During this echocardiogram patients receive doses of a medication called dobutamine that stimulates the heart to beat stronger and faster
The purpose of this study is to evaluate the accuracy of MCE compared to stress echocardiography at detecting coronary artery disease CAD
Detailed Description:
Stress echocardiography has become a valuable technique for the non-invasive detection of coronary artery disease CAD Its accuracy has been shown to be superior to that of the exercise electrocardiogram and comparable to that of myocardial perfusion imaging Myocardial contrast echocardiography MCE offers the potential to evaluate tissue perfusion at the level where oxygen transfer to the myocytes occurs MCE can therefore provide information regarding the functional status of the myocardial microvasculature and presence of blood flow disparity The purpose of this study is to evaluate the accuracy of MCE compared to stress echocardiography We will correlate these results with findings from coronary angiography and compare the ability of those techniques to detect CAD
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 99-H-0077 | None | None | None |