Ignite Creation Date:
2024-06-16 @ 11:50 AM
Last Modification Date:
2024-10-26 @ 3:31 PM
Study NCT ID:
NCT06446011
Status:
RECRUITING
Last Update Posted:
2024-06-06
First Post:
2023-12-07
Brief Title:
Effects of RCT on Periapical Healing Inflammatory Markers and Kidney Function Indicators in CKD Patients With AP
Sponsor:
Postgraduate Institute of Dental Sciences Rohtak
Organization:
Postgraduate Institute of Dental Sciences Rohtak
Study Overview
Official Title:
Potential Effects of Non-surgical Endodontic Treatment on Periapical Healing Inflammatory Markers and Kidney Function Indicators in Chronic Kidney Disease Patients With Apical Periodontitis- Interventional Study
Status:
RECRUITING
Status Verified Date:
2023-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this prospective study is to determine the effect of non-surgical root canal treatment in chronic kidney disease patients and healthy patients with apical periodontitis
Detailed Description:
It has been found that there is an association between prevalence of odontogenic infection and systemic diseases An elevated level of systemic cytokines has been observed in conjunction with both AP and CKD The proinflammatory status and impaired immune response associated with systemic diseases chronic kidney disease can affect the reparative response of the dental pulp and periapical healing One study observed significant positive relation between number of diagnosed AP and urea serum level A 435-mgdL increase in the urea serum level could be expected per 1-unit increase in the number of teeth with AP Improving oral health care through nonsurgical endodontic treatmentNSET may improve the systemic inflammatory status and improve renal function
The aim of this prospective study is to determine the effect of non-surgical root canal treatment in chronic kidney disease patients and healthy patients with apical periodontitis
1 Clinical and radiographic success rate will be considered as primary outcome will be checked at baseline6months12months follow upPeriapical status will be checked according to periapical index given by Orstavik
2 Reduction in inflammatoryhsCRP and kidney makersserum urea creatinine eGFR will be considered as secondary outcome will be checked at baseline3months6months follow up
The aim of this prospective study is to determine the effect of non-surgical root canal treatment in chronic kidney disease patients and healthy patients with apical periodontitis
1 Clinical and radiographic success rate will be considered as primary outcome will be checked at baseline6months12months follow upPeriapical status will be checked according to periapical index given by Orstavik
2 Reduction in inflammatoryhsCRP and kidney makersserum urea creatinine eGFR will be considered as secondary outcome will be checked at baseline3months6months follow up
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None