Ignite Creation Date:
2024-06-16 @ 11:50 AM
Last Modification Date:
2024-10-26 @ 3:31 PM
Study NCT ID:
NCT06442228
Status:
RECRUITING
Last Update Posted:
2024-07-03
First Post:
2024-05-14
Brief Title:
History of Polycystic Ovary Syndrome in First-degree Relatives
Sponsor:
Etlik Zubeyde Hanım Womens Health Care Training and Research Hospital
Organization:
Etlik Zubeyde Hanım Womens Health Care Training and Research Hospital
Study Overview
Official Title:
Investigation of the History of Polycystic Ovary Syndrome in First-degree Relatives of Male Partners of Couples Presenting for Infertility Treatment
Status:
RECRUITING
Status Verified Date:
2024-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
PCOS
Brief Summary:
The aim of this study was to investigate the semen analysis results of male patients with first-degree relatives meeting the diagnostic criteria for PCOS
Detailed Description:
Polycystic ovary syndrome PCOS is an endocrine metabolic disorder characterised by menstrual irregularity anovulation clinical andor biochemical signs of hyper androgenism hirsutism andor acne micropolycystic ovaries and metabolic abnormalities
This syndrome is clustered in family members and appears to be inherited through an oligogenic mechanism 12 As a result of familial clustering of the PCOS phenotype metabolic risks have been shown to increase in family members independent of gender
The presence of a genetic background in the etiopathogenesis of PCOS means that men may also have signs and symptoms equivalent to PCOS In addition the genes responsible for PCOS susceptibility in women are also transferred to male relatives of these individuals Hormonal and metabolic abnormalities have been identified in male relatives of women with PCOS These men have shown a higher prevalence of early-onset 35 years androgenetic alopecia AGA type 2 DM and cardivascular diseases In addition prostate cancer benign prostatic hyperplasia BPH and prostatitis have also been defined more frequently in this group of individuals 13
In addition differences in responses to gonadotropin-releasing hormone GnRH and FSH and LH levels were found in the brothers of women with PCOS compared to control groups
According to genome studies GWAS FSHB gene on chromosome 11p141 represents the PCOS susceptibility focus in women 1 Genetic variations in FSHB affect male reproductive function In fact polymorphisms of the FSHB promoter have been associated with lower sperm count higher LH lower FSH and lower testicular volume 34
In the light of this information in this study it was planned to evaluate the comparison of semen analysis results of male patients with a first-degree relative diagnosed with PCOS with the control group
This syndrome is clustered in family members and appears to be inherited through an oligogenic mechanism 12 As a result of familial clustering of the PCOS phenotype metabolic risks have been shown to increase in family members independent of gender
The presence of a genetic background in the etiopathogenesis of PCOS means that men may also have signs and symptoms equivalent to PCOS In addition the genes responsible for PCOS susceptibility in women are also transferred to male relatives of these individuals Hormonal and metabolic abnormalities have been identified in male relatives of women with PCOS These men have shown a higher prevalence of early-onset 35 years androgenetic alopecia AGA type 2 DM and cardivascular diseases In addition prostate cancer benign prostatic hyperplasia BPH and prostatitis have also been defined more frequently in this group of individuals 13
In addition differences in responses to gonadotropin-releasing hormone GnRH and FSH and LH levels were found in the brothers of women with PCOS compared to control groups
According to genome studies GWAS FSHB gene on chromosome 11p141 represents the PCOS susceptibility focus in women 1 Genetic variations in FSHB affect male reproductive function In fact polymorphisms of the FSHB promoter have been associated with lower sperm count higher LH lower FSH and lower testicular volume 34
In the light of this information in this study it was planned to evaluate the comparison of semen analysis results of male patients with a first-degree relative diagnosed with PCOS with the control group
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None