Ignite Creation Date:
2024-06-16 @ 11:50 AM
Last Modification Date:
2024-10-26 @ 3:31 PM
Study NCT ID:
NCT06447246
Status:
ENROLLING_BY_INVITATION
Last Update Posted:
2024-07-11
First Post:
2024-05-29
Brief Title:
Respiratory Effects of Obesity in Children Longitudinal Consequences After 6 Years of Aging
Sponsor:
University of Texas Southwestern Medical Center
Organization:
University of Texas Southwestern Medical Center
Study Overview
Official Title:
Respiratory Effects of Obesity in Children Longitudinal Consequences After 6 Years of Aging
Status:
ENROLLING_BY_INVITATION
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of the study is to re-examine body composition respiratory function exercise tolerance and dyspnea on exertion DOE in children with obesity CWO and children without obesity CWOO who were originally studied as 8-12-year-olds between 2016-2023 ie originally Tanner score 3 90 participants 26 CWOO 64 CWO
Detailed Description:
The prevalence of childhood obesity increases with age 207 aged 6-11 222 aged 12-19 NHANES 2017-2020 CWO compared with CWOO are more likely to have chronic health conditions
Results from the investigators prior grant HL136643 show that over one year CWO can add four times as much fat weight as CWOO However it is unknown if this rate of increase in fat weight continues into adolescence and early adulthood and whether respiratory function exercise tolerance or DOE are progressively worsened by increasing obesity Furthermore there could be a sex difference in the effects of obesity given the different growth characteristics for boys and girls
The investigators long-term objective is to investigate the effects of 6 years of aging on body composition respiratory function exercise tolerance and DOE in CWO and CWOO
Specific Aims The investigators will test the following hypotheses in CWO and CWOO after 6 years of aging
Aim 1 CWO originally studied at 8-12 years old will demonstrate a greater increase in fat weight and lower respiratory function ie altered pulmonary function breathing mechanics at rest than in CWOO originally studied at 8-12 years old
Aim 2 CWO originally studied at 8-12 years old will demonstrate lower exercise tolerance measured during graded cycle ergometry as evidenced by peak V O2 in mlminkg ie physical fitness than in CWOO originally studied at 8-12 years old but not lower cardiorespiratory fitness as evidenced by peak V O2 in of predicted based on ideal body wt ie cardiorespiratory fitness
Aim 3 CWO originally studied at 8-12 years old will demonstrate greater DOE as evidenced by increased ratings of perceived breathlessness during constant load exercise cycling than in CWOO originally studied at 8-12 years old and
Results from the investigators prior grant HL136643 show that over one year CWO can add four times as much fat weight as CWOO However it is unknown if this rate of increase in fat weight continues into adolescence and early adulthood and whether respiratory function exercise tolerance or DOE are progressively worsened by increasing obesity Furthermore there could be a sex difference in the effects of obesity given the different growth characteristics for boys and girls
The investigators long-term objective is to investigate the effects of 6 years of aging on body composition respiratory function exercise tolerance and DOE in CWO and CWOO
Specific Aims The investigators will test the following hypotheses in CWO and CWOO after 6 years of aging
Aim 1 CWO originally studied at 8-12 years old will demonstrate a greater increase in fat weight and lower respiratory function ie altered pulmonary function breathing mechanics at rest than in CWOO originally studied at 8-12 years old
Aim 2 CWO originally studied at 8-12 years old will demonstrate lower exercise tolerance measured during graded cycle ergometry as evidenced by peak V O2 in mlminkg ie physical fitness than in CWOO originally studied at 8-12 years old but not lower cardiorespiratory fitness as evidenced by peak V O2 in of predicted based on ideal body wt ie cardiorespiratory fitness
Aim 3 CWO originally studied at 8-12 years old will demonstrate greater DOE as evidenced by increased ratings of perceived breathlessness during constant load exercise cycling than in CWOO originally studied at 8-12 years old and
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None