Ignite Creation Date:
2024-06-16 @ 11:50 AM
Last Modification Date:
2024-10-26 @ 3:31 PM
Study NCT ID:
NCT06445712
Status:
RECRUITING
Last Update Posted:
2024-06-06
First Post:
2024-05-22
Brief Title:
Examining the Role of Pain in the Link Between Early Childhood Adversity and Psychopathology
Sponsor:
Washington University School of Medicine
Organization:
Washington University School of Medicine
Study Overview
Official Title:
Examining the Role of Pain in the Link Between Early Childhood Adversity and Psychopathology
Status:
RECRUITING
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The goal of this study is to investigate the role of physical pain in the link between childhood adversity and later psychopathology Children who are participating in a larger longitudinal study will be asked to submerge their hand in cold water and hold it in the cold water as long as possible Participants will do this twice once alone and once holding the hand of their parent to examine the role of parental support in pain development The study will examine self-report of pain and salivary cortisol response to pain It is hypothesized that children who have been exposed to more adversity will experience increased pain response and increased psychopathology symptoms It is expected that higher social support in the family will decrease this relationship
Detailed Description:
This study will initiate a program of prospective research linking early life adversity to both pain and psychopathology symptoms in the pre-adolescent period This study will examine these links using an existing longitudinal sample of 65-95 year-old children experiencing familial stress The project will examine the relationship between dysregulation and pain sensitivity from the behavioral perspective but also through HPA axis dysregulation Finally the project will probe parental support as a moderator on the relationship between dysregulation and pain and psychopathology symptoms The project will use a novel adaptation of the cold pressor test to examine experimental pain sensitivity as a function of parental support by including a condition in which the child holds the hand of their parent during the task The project will also examine the neural basis of social support through parent-child brain synchronization Support for the proposed model may indicate that interventions that increase parental support might decrease both pain and psychopathology
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| UL1TR002345 | NIH | None | httpsreporternihgovquickSearchUL1TR002345 |