Ignite Creation Date:
2024-06-16 @ 11:50 AM
Last Modification Date:
2024-10-26 @ 3:31 PM
Study NCT ID:
NCT06444477
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-06-05
First Post:
2024-05-14
Brief Title:
Molecular Analysis of Thrombocytopenia and Cancer MATAC Investigating Antigenic Mimicry Between Platelets and Tumor Cells in Patients With Immune Thrombocytopenia ITP Associated With Cancer
Sponsor:
University Hospital Bordeaux
Organization:
University Hospital Bordeaux
Study Overview
Official Title:
Molecular Analysis of Thrombocytopenia and Cancer MATAC Investigating Antigenic Mimicry Between Platelets and Tumor Cells in Patients With Immune Thrombocytopenia ITP Associated With Cancer
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
MATAC
Brief Summary:
The association between hematologic malignancies and ITP is well described but this link is much less clear with solid cancers In cases of ITP associated with cancers specific cancer treatment can lead to remission or even cure of ITP Thus our hypothesis was that chronic expression of GPIIB by tumor cells could have initiated an autoimmune loop against GPIIB leading to the onset and perpetuation of ITP
Detailed Description:
Autoimmune thrombocytopenia also known as immune thrombocytopenic purpura ITP is a rare autoimmune disease characterized by platelet destruction and impaired production posing a life-threatening risk due to bleeding complications The pathophysiology of ITP involves complex mechanisms including both defective platelet production and auto-reactivity of B and T lymphocytes leading to the production of autoantibodies against platelets found in 35 to 55 of cases Additionally in the context of neoplasia some patients may develop varying degrees of thrombocytopenia exacerbating morbidity and mortality A multicenter retrospective study will collect data from routine care including birth date gender biological parameters related to ITP dates of treatment initiation and diagnosis of ITP and cancer types of treatments and outcomes such as survival or death without additional medical interventions or appointments
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None