Ignite Creation Date:
2024-06-16 @ 11:50 AM
Last Modification Date:
2024-10-26 @ 3:31 PM
Study NCT ID:
NCT06448546
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-06-07
First Post:
2024-06-03
Brief Title:
Gut Microbiomes in HD
Sponsor:
University of Central Florida
Organization:
University of Central Florida
Study Overview
Official Title:
Investigating the Role of the Gut Microbiome in Huntingtons Disease
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to find out if there is a connection between the naturally occurring bacteria in our bodies and the progression of Huntington disease The investigators are trying to determine if patients who are diagnosed with adult-onset HD and who exhibit a rapid rate of disease progression have unique populations of bacteria in their gut as compared to patients with slower progression
Detailed Description:
Two of the most common non-neurological features of Huntington disease HD are progressive weight loss and metabolic dysfunction However a small proportion of HD patients are pathologically overweight despite having similar CAG repeat lengths as pathologically underweight patients The investigators hypothesize this spectrum of weight abnormalities may be caused by HD-related metabolic dysfunction
Pathological weight loss is recapitulated in transgenic HD model mice expressing fragments of human huntingtin HTT either transgenically34 or knocked-in to a portion of the mouse HD homolog Hdh gene5 Conversely pathological weight gain is recapitulated in transgenic HD model mice expressing full-length human HTT either along with the full complement of Hdh67 or in Hdh-null backgrounds89
In Hdh-null background transgenic HD model mice which are pathologically overweight circadian feeding is disrupted despite maintenance of naturally nocturnal circadian activity Interestingly circadian feeding patterns are restored by suppression of brain HTT unpublished Dr Amber Southwell suggesting that HTT plays a role in circadian feeding regulation Furthermore when circadian feeding patterns are artificially restored with scheduled feeding striatal HTT is temporarily suppressed while metabolic markers and body weight are normalized unpublished Dr Amber Southwell Together this demonstrates that HTT is involved in gut-brain feedback but since HTT suppression during scheduled feedings is transient while metabolic effects are lasting HTT is likely not the master regulator of this feedback loop Instead the gut microbiome may influence this pathway possibly contributing to the onset andor progression of HD
Pathological weight loss is recapitulated in transgenic HD model mice expressing fragments of human huntingtin HTT either transgenically34 or knocked-in to a portion of the mouse HD homolog Hdh gene5 Conversely pathological weight gain is recapitulated in transgenic HD model mice expressing full-length human HTT either along with the full complement of Hdh67 or in Hdh-null backgrounds89
In Hdh-null background transgenic HD model mice which are pathologically overweight circadian feeding is disrupted despite maintenance of naturally nocturnal circadian activity Interestingly circadian feeding patterns are restored by suppression of brain HTT unpublished Dr Amber Southwell suggesting that HTT plays a role in circadian feeding regulation Furthermore when circadian feeding patterns are artificially restored with scheduled feeding striatal HTT is temporarily suppressed while metabolic markers and body weight are normalized unpublished Dr Amber Southwell Together this demonstrates that HTT is involved in gut-brain feedback but since HTT suppression during scheduled feedings is transient while metabolic effects are lasting HTT is likely not the master regulator of this feedback loop Instead the gut microbiome may influence this pathway possibly contributing to the onset andor progression of HD
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None