Ignite Creation Date:
2024-06-16 @ 11:50 AM
Last Modification Date:
2024-10-26 @ 3:31 PM
Study NCT ID:
NCT06447220
Status:
RECRUITING
Last Update Posted:
2024-07-12
First Post:
2024-05-19
Brief Title:
Washed Microbiota Transplantation for Malnutrition
Sponsor:
The Second Hospital of Nanjing Medical University
Organization:
The Second Hospital of Nanjing Medical University
Study Overview
Official Title:
Washed Microbiota Transplantation for Malnutrition
Status:
RECRUITING
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Malnutrition is a pathological condition in which dietary intake fails to meet the bodys energetic or nutritional needs It may be caused by macronutrient or micronutrient deficiencies high energy expenditure impaired nutrient absorption or assimilation Malnutrition can affect all stages of life In adults malnutrition is strongly associated with poor clinical outcomes such as increased morbidity increased mortality and prolonged hospitalization In children malnutrition can lead to growth retardation cognitive impairment and immune dysfunction
Detailed Description:
The gut microbiota of malnourished patients is different from that of healthy people The diversity of the gut microbiota of patients with severe malnutrition reduced and the abundance of Proteobacteria significantly increased as well as pathogenic genera such as Klebsiella Escherichia coli Shigella and Streptococcus This suggests that gut microbiota plays an important role in the occurrence and development of malnutrition Dietary intervention targeting gut microbiota can quickly improve childrens malnutrition promote weight gain and increase protein levels that promote bone growth and nerve development Exclusive enteral nutrition combined with immediate washed microbiota transplantationWMT can rapidly improve the nutritional status of patients with Crohns disease compared with those with delayed WMT Gut microbiota has been confirmed to be closely related to malnutrition Improving the disordered gut microbiota in malnourished patients may become a potential treatment
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None