Ignite Creation Date:
2024-06-16 @ 11:49 AM
Last Modification Date:
2024-10-26 @ 3:30 PM
Study NCT ID:
NCT06432712
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-05-29
First Post:
2024-05-23
Brief Title:
Comparison of Post Operative Endodontic Pain in Patients With Irreversible Pulpitis Treated With and Without Dexamethasone
Sponsor:
Shoaib Rahim
Organization:
Foundation University Islamabad
Study Overview
Official Title:
Comparison of Post Operative Endodontic Pain in Patients With Irreversible Pulpitis Treated With and Without Dexamethasone
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Root canal procedure is a common procedure in dentistry Acute inflammatory response in peri-radicular tissues after root canal treatment is the main cause of post op pain
Potential Solution The current study will assess effect of dexamethasone administered as periapical infiltration in reducing post-instrumentation pain
Research Goal Pain score of patients treated with dexamethasone infiltration will be less compared to patients treated with NSAIDS alone after canal instrumentation
Potential Solution The current study will assess effect of dexamethasone administered as periapical infiltration in reducing post-instrumentation pain
Research Goal Pain score of patients treated with dexamethasone infiltration will be less compared to patients treated with NSAIDS alone after canal instrumentation
Detailed Description:
Acute inflammatory response in peri-radicular tissues after root canal treatment is the main cause of post op pain The peak inflammatory response occurs after 24 - 48 hours of root canal instrumentation As management of post-endodontic pain is still a challenge for clinicians several drugs which include NSAIDs acetaminophen opioids and steroids are used to reduce the inflammatory response Corticosteroids possess anti-inflammatory efficacy and they prevent the production and release of inflammatory mediators at the site of tissue injury thus reducing the signs symptoms of inflammation such as pain swelling loss of function Dexamethasone is a potent corticosteroid that has the ability to reduce the production of proinflammatory cytokines Dexamethasone can be administered orally or as an intraosseous intra ligament periapical intracanal injection Dexamethasone is effective in alleviating pain in first 24 hours post endodontic treatment Previous research on the effect of dexamethasone injection on post-endodontic treatment pain in patients presenting with necrotic pulp treated with single visit endodontic treatment reported 25 post operative pain occurrence and 9 when treated with dexamethasone
Study Goal The current study will assess effect of dexamethasone administered as periapical infiltration in reducing post-instrumentation pain as compared to the prescription of NSAIDs only If dexamethasone infiltration is effective in pain relief after endodontic treatment it can be a useful adjunct in managing patients presenting with acute pulpal pain
Study Goal The current study will assess effect of dexamethasone administered as periapical infiltration in reducing post-instrumentation pain as compared to the prescription of NSAIDs only If dexamethasone infiltration is effective in pain relief after endodontic treatment it can be a useful adjunct in managing patients presenting with acute pulpal pain
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
False
Is an FDA AA801 Violation?:
None