Ignite Creation Date:
2024-06-16 @ 11:49 AM
Last Modification Date:
2024-10-26 @ 3:30 PM
Study NCT ID:
NCT06435637
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-05-30
First Post:
2024-04-22
Brief Title:
Effects of Ingesting Multiple Boluses of Collagen on Muscle Skin Connective Protein Synthesis in Vivo in Humans
Sponsor:
Maastricht University Medical Center
Organization:
Maastricht University Medical Center
Study Overview
Official Title:
Collagen Digestion and Amino Acid Absorption Kinetics and the Effect on Muscle Skin
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
CODIAK
Brief Summary:
Rationale Collagen protein is the central structural component of extracellular connective tissues within skeletal muscle bone cartilage and skin Dietary collagen peptides are a promising protein source to deliver the specific amino acid precursors required to support an increase in connective tissue protein synthesis across several tissues eg muscle skin However the digestion and absorption kinetics of multiple boluses of collagen peptides and the subsequent impact on muscle and skin connective tissue protein synthesis rates have not yet been assessed in vivo in humans
Objective To assess the impact of ingestion of multiple boluses of collagen peptides on muscle connective and skin protein synthesis in vivo in humans
Study design Double-blind parallel-group placebo-controlled intervention study
Study population 20 healthy young males aged 18-35 years
Intervention Participants will perform unilateral resistance exercise followed by the ingestion of either 100 g of collagen peptides in boluses or a non-caloric placebo flavoured water drinks while all drinks will contain vitamin C Continuous intravenous stable isotope amino acid tracer infusions will be applied plasma skin and muscle samples will be collected in order to assess protein synthesis rates in skin and muscle tissue
Main study parametersendpoints Primary study parameters are muscle connective protein synthesis rates Secondary study parameters are skin and myofibrillar protein synthesis rates plasma amino acid concentrations and body composition
Objective To assess the impact of ingestion of multiple boluses of collagen peptides on muscle connective and skin protein synthesis in vivo in humans
Study design Double-blind parallel-group placebo-controlled intervention study
Study population 20 healthy young males aged 18-35 years
Intervention Participants will perform unilateral resistance exercise followed by the ingestion of either 100 g of collagen peptides in boluses or a non-caloric placebo flavoured water drinks while all drinks will contain vitamin C Continuous intravenous stable isotope amino acid tracer infusions will be applied plasma skin and muscle samples will be collected in order to assess protein synthesis rates in skin and muscle tissue
Main study parametersendpoints Primary study parameters are muscle connective protein synthesis rates Secondary study parameters are skin and myofibrillar protein synthesis rates plasma amino acid concentrations and body composition
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None