Ignite Creation Date:
2024-06-16 @ 11:49 AM
Last Modification Date:
2024-10-26 @ 3:31 PM
Study NCT ID:
NCT06438419
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-06-07
First Post:
2024-05-27
Brief Title:
Parkinsonism-Related Oscillations in the Cortico-Basal Ganglia-Thalamic Network During Movement Beyond the Frequency Range
Sponsor:
University Hospital Bordeaux
Organization:
University Hospital Bordeaux
Study Overview
Official Title:
Parkinsonism-Related Oscillations in the Cortico-Basal Ganglia-Thalamic Network During Movement Beyond the Frequency Range
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
MOVOSCILLCBGT
Brief Summary:
Expression of hypokinetic and hyperkinetic motor symptoms in Parkinsons disease PD is associated with pathological synchronous oscillations of neuronal activity local field potentialLFP in the cortico-subcortical network with a wide frequency range In the present project we propose to study cortico-subcortical oscillations and their synchronization in patients operated for PD subthalamic deep brain stimulation STN-DBS during distinct pharmacological and stimulation conditions hypokinetic and hyperkinetic using a simple motor task
Detailed Description:
To define the link between the characteristics of neuronal oscillations frequency amplitude phase relationship within the cortico-subcortical network and the movement we designed a simple motor task of grippingpulling a lever The LFPs will be collected at the cortical and subcortical levels STN during the motor task using a high-resolution EEG HR-EEG and the Percept system Medtronic Recordings will be realized in four conditions without pharmacological treatment and without stimulation Off condition without pharmacological treatment and during stimulation DBS condition during pharmacological treatment and without stimulation DOPA condition and during pharmacological treatment and stimulation DOPADBS condition
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None