Ignite Creation Date:
2024-06-16 @ 11:49 AM
Last Modification Date:
2024-10-26 @ 3:30 PM
Study NCT ID:
NCT06433388
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-05-29
First Post:
2024-05-22
Brief Title:
Perirenal Fats of Chronic Kidney Disease in Patients With Fatty Liver Disease
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
Perirenal Fats of Chronic Kidney Disease in Patients With Fatty Liver Disease
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Exploring the association of perirenal fat thickness assessed by MRI in CKD patients with FLD
Detailed Description:
Fatty liver disease FLD is caused by an accumulation of excessive fat in the liver that leads to liver damage It has been noticed that fatty liver disease affects not only liver diseases but also extra-hepatic organ systems such as the cardiovascular and renal systems Increasing the prevalence of FLD has a great association with increasing the risk of cardiovascular diseases chronic kidney diseases and Type 2 diabetes mellitus Hypertension insulin resistance and abdominal obesity are risk factors that are shared by FLD and CKD Moreover patients with CKD have a great prevalence of developing FLD and CKD incidence is increased by the presence of FLD
Obesity is one of the most comorbidities over the world it is related and increase the risk of cardio metabolic disease as well as it is a strong risk factor for chronic kidney disease CKD and the prevalence of both conditions is rising worldwide Several recent epidemiologic studies have shown that obesity and the metabolic syndrome are independent predictors of CKD The most common method for defining obesity is based on BMIweight kilograms divided by the square of height meters
previously abdominal fat distribution have been measured by BMI waist to hip ratio WHR OR Waist circumference Although waist circumference was noted to be a reliable predictor of visceral fat many interfering factors may also reduce the reliability of WC in estimating abdominal fat deposition as well as the associated risk for CKD like ageing and normal difference in fat distribution between the two genders Based on these considerations we presume that per renal fat thickness measurement by MRI may better reflect the risks commonly associated with increased visceral fat accumulation and particularly those related to renal function impairment
Chronic kidney disease is defined as impairment or structural damage to kidney or kidney function It manifested by reduction in estimated glomerular rate eGFR for at least 3 months It presented with proteinuria or albuminuria hematuria The best diagnosis by biopsy showing renal impairment or by imaging ultrasound CKD associated with morbidity and mortality condition especially in developing countries so it has been necessary to early detection to prevent CKD progression and associated complications thus improving patient outcomes and reducing the impact of CKD on health-care resources
FLD begins with liver lipid accumulation and marked hepatic fat accumulation is a risk factor for disease progression Liver biopsy is the golden for diagnosis and assessment of the severity of steatosis and grading of fibrosis although being invasive and difficult method Ultrasound and magnetic resonance imaging MRI biomarkers of liver fat Gives the advantage diagnose FLD as it is non-invasive imaging biomarkers to diagnose FLD steatosis and fibrosis
Therefore the aim of this study is to determine the independent association of Perirenal fat assessment by MRI with the main markers of kidney function such as estimated glomerular filtration rate eGFR albuminuria as well as with serum urate values on one side and grading of fibrosis and steatosis in FLD patients on the other side
Obesity is one of the most comorbidities over the world it is related and increase the risk of cardio metabolic disease as well as it is a strong risk factor for chronic kidney disease CKD and the prevalence of both conditions is rising worldwide Several recent epidemiologic studies have shown that obesity and the metabolic syndrome are independent predictors of CKD The most common method for defining obesity is based on BMIweight kilograms divided by the square of height meters
previously abdominal fat distribution have been measured by BMI waist to hip ratio WHR OR Waist circumference Although waist circumference was noted to be a reliable predictor of visceral fat many interfering factors may also reduce the reliability of WC in estimating abdominal fat deposition as well as the associated risk for CKD like ageing and normal difference in fat distribution between the two genders Based on these considerations we presume that per renal fat thickness measurement by MRI may better reflect the risks commonly associated with increased visceral fat accumulation and particularly those related to renal function impairment
Chronic kidney disease is defined as impairment or structural damage to kidney or kidney function It manifested by reduction in estimated glomerular rate eGFR for at least 3 months It presented with proteinuria or albuminuria hematuria The best diagnosis by biopsy showing renal impairment or by imaging ultrasound CKD associated with morbidity and mortality condition especially in developing countries so it has been necessary to early detection to prevent CKD progression and associated complications thus improving patient outcomes and reducing the impact of CKD on health-care resources
FLD begins with liver lipid accumulation and marked hepatic fat accumulation is a risk factor for disease progression Liver biopsy is the golden for diagnosis and assessment of the severity of steatosis and grading of fibrosis although being invasive and difficult method Ultrasound and magnetic resonance imaging MRI biomarkers of liver fat Gives the advantage diagnose FLD as it is non-invasive imaging biomarkers to diagnose FLD steatosis and fibrosis
Therefore the aim of this study is to determine the independent association of Perirenal fat assessment by MRI with the main markers of kidney function such as estimated glomerular filtration rate eGFR albuminuria as well as with serum urate values on one side and grading of fibrosis and steatosis in FLD patients on the other side
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None