Ignite Creation Date:
2024-06-16 @ 11:49 AM
Last Modification Date:
2024-10-26 @ 3:30 PM
Study NCT ID:
NCT06430645
Status:
RECRUITING
Last Update Posted:
2024-05-28
First Post:
2024-05-09
Brief Title:
Effects of Esketamine on Recovery of Consciousness After Propofol Anesthesia
Sponsor:
Beijing Tiantan Hospital
Organization:
Beijing Tiantan Hospital
Study Overview
Official Title:
Effects of Esketamine on Recovery of Consciousness After Propofol Anesthesia
Status:
RECRUITING
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Esketamine is an antagonist of N-methyl-d-aspartate NMDA receptor different from other gamma-aminobutyric acid GABA receptor agonists Recent studies showed that subanesthetic doses of ketamine not only deepen anesthesia but also accelerate recovery from isoflurane anesthesia in mice It is necessary to verify if it applies to human Besides inducing behavioral unresponsiveness an optimal and important goal of general anesthesia is to prevent connected consciousness The results of many studies support the conclusion that anesthesia-related unconsciousness is a consistent functional disconnection of lateral frontoparietal networksThe goal of this clinical trial is to learn if subanaesthetic doses of esketamine works to accelerate the recovery of consciousness from propofol anesthesia It will also learn about the change of brain network when administrated the esketamine during propofol anesthesia The main questions it aims to answer are
1 Does subanaesthetic doses of esketamine can accelerate recovery from propofol anaesthesia
2 What will happen to brain network connection after different doses of esketamine during propofol anesthesia
1 Does subanaesthetic doses of esketamine can accelerate recovery from propofol anaesthesia
2 What will happen to brain network connection after different doses of esketamine during propofol anesthesia
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None