Ignite Creation Date:
2024-06-16 @ 11:48 AM
Last Modification Date:
2024-10-26 @ 3:30 PM
Study NCT ID:
NCT06435962
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-06-04
First Post:
2024-04-02
Brief Title:
Productive Value of Sonographic Measurement of Optic Nerve in Transitional Multiple
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
Productive Value of Sonographic Measurement of Optic Nerve in Transitional Multiple
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
1to evaluate the potential role of the optic nerve diameter OND determined by ultrasonography and and visual nerve function by visual evoked potential as a biomarker of early axonal loss and disability in patients with relapsing remitting multiple sclerosis RRMS
Detailed Description:
Multiple sclerosis MS is one of the leading disabling neurological diseases in young Adults Characteristically reliable biomarkers for every independent MS pathogenic factor are extremely important
1 Increasing evidence has demonstrated that neuronal and axonal damage within the central nervous system CNS contributes substantially to the development of permanent disability in patients with MS
2 Thus reliable economic and easily assessable complementary surrogate biomarkers for axonal Degeneration and consequently disability remain to be identified
3 The optic nerve can serve as a useful clinical tool for studying these characteristics and can be used to Measure and monitor the pathological process of the disease The optic nerve is most commonly assessed by ophthalmoscopy and magnetic resonance imaging MRI But measurement of the optic nerve diameter OND by a simple ultrasound examination and measurement of optic nerve function by visual evoked potential might permit a rough estimation of the extent of brain parenchymal involvement and the consequent global cerebral atrophy and disability In relapsing-remitting MS RRMS patients
The analysis of the diameter of the optic nerve showed that it is possible To detect its atrophy in the affected eyes with optic neuritis and to a lesser extent in un affected eye Also the visual evoked potential study has the ability to quantify the unsuspected clinically silent lesions hence allows confirming the vague deterioration of visual functions
1 Increasing evidence has demonstrated that neuronal and axonal damage within the central nervous system CNS contributes substantially to the development of permanent disability in patients with MS
2 Thus reliable economic and easily assessable complementary surrogate biomarkers for axonal Degeneration and consequently disability remain to be identified
3 The optic nerve can serve as a useful clinical tool for studying these characteristics and can be used to Measure and monitor the pathological process of the disease The optic nerve is most commonly assessed by ophthalmoscopy and magnetic resonance imaging MRI But measurement of the optic nerve diameter OND by a simple ultrasound examination and measurement of optic nerve function by visual evoked potential might permit a rough estimation of the extent of brain parenchymal involvement and the consequent global cerebral atrophy and disability In relapsing-remitting MS RRMS patients
The analysis of the diameter of the optic nerve showed that it is possible To detect its atrophy in the affected eyes with optic neuritis and to a lesser extent in un affected eye Also the visual evoked potential study has the ability to quantify the unsuspected clinically silent lesions hence allows confirming the vague deterioration of visual functions
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None