Ignite Creation Date:
2024-06-16 @ 11:48 AM
Last Modification Date:
2024-10-26 @ 3:30 PM
Study NCT ID:
NCT06434129
Status:
RECRUITING
Last Update Posted:
2024-05-30
First Post:
2024-05-21
Brief Title:
Role of Diffusion Tensor-magnetic Resonance Imaging in Investigating Sensorineural Hearing Loss
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
Role of Diffusion Tensor-magnetic Resonance Imaging in Investigating Sensorineural Hearing Loss
Status:
RECRUITING
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
DTI and auditory tractography can be incorporated into the diagnostic toolkit for patients who are scheduled to undergo cochlear implantation and whose standard assessments have been unable to determine the functional integrity of the auditory pathway These techniques aid in decision-making processes regarding potential outcomes determining the optimal side for implantation providing counseling regarding the possibility of limited benefits from surgery and considering alternative forms of rehabilitation The investigators including patients with varying degrees of hearing loss as well as patients with normal radiological findings who are scheduled for cochlear implantation The ultimate goal is to create a comprehensive map across the entire hearing spectrum and validate the findings of this study
Detailed Description:
Hearing is a complex process in which many parts of the ear contribute to transmit signals to the brain The auditory system consists of both peripheral structures external middle and inner earas well as central regions cochlear nuclei in the medulla oblongata superior olivary nuclei and lateral lemniscus in the pons inferior colliculus in the midbrain medial geniculate nuclei in the thalamus and auditory cortex in the superior temporal Heschl gyrus Most of auditory fibres undergo a contralateral decussation to the opposite superior olive in the region known as the trapezoid body
The broad term sensorineural hearing loss SNHL It accounts for a substantial proportion of hearing impairment cases globally affecting individuals of various age groups It has been used by clinicians to refer to either malfunctioning inner ear or a retrocochlear problem affecting the canalicular vestibule-chochlear VIII cranial nerve and cerebellopontine angle or that involves the higher central auditory nuclei and neural tracts Identifying the etiology of hearing loss is valuable to establish a treatment strategy that can help to prevent or slow down complete loss of auditory function
The central auditory structures are involved in various processes that may occur in isolation from those involving peripheral receptors SNHL can be a consequence of different conditions including viral infection tumor ischemia multiple sclerosis or congenital malformations
Despite continuous efforts to delineate the pathophysiological attributes of SNHL the aetiology remains mostly unclear with nearly 90 of cases being idiopathic Therefore finding a method to accurately predict microstructural changes of the auditory circuit is extremely important
Conventional imaging modalities including computed tomography CT and magnetic resonance imaging MRI have offered invaluable insights into the macroscopic changes associated with SNHL such as cochlear morphology and structural abnormalities However these techniques lack the sensitivity to discern subtle alterations occurring at the microstructural level impeding a comprehensive understanding of the underlying pathophysiological processes
DTI-MRIs ability to capture subtle changes in tissue microstructure makes it an ideal candidate for probing the intricate auditory pathways affected by SNHL By quantifying the diffusion of water molecules along axonal pathways DTI-MRI can uncover alterations in the integrity of auditory neural connections which are often missed by conventional imaging methods Furthermore DTI-derived metrics such as fractional anisotropy FA axial diffusivity AD radial diffusivity RD and mean diffusivity MD offer quantitative measures to characterize the white matter integrity and myelination in auditory pathways
The broad term sensorineural hearing loss SNHL It accounts for a substantial proportion of hearing impairment cases globally affecting individuals of various age groups It has been used by clinicians to refer to either malfunctioning inner ear or a retrocochlear problem affecting the canalicular vestibule-chochlear VIII cranial nerve and cerebellopontine angle or that involves the higher central auditory nuclei and neural tracts Identifying the etiology of hearing loss is valuable to establish a treatment strategy that can help to prevent or slow down complete loss of auditory function
The central auditory structures are involved in various processes that may occur in isolation from those involving peripheral receptors SNHL can be a consequence of different conditions including viral infection tumor ischemia multiple sclerosis or congenital malformations
Despite continuous efforts to delineate the pathophysiological attributes of SNHL the aetiology remains mostly unclear with nearly 90 of cases being idiopathic Therefore finding a method to accurately predict microstructural changes of the auditory circuit is extremely important
Conventional imaging modalities including computed tomography CT and magnetic resonance imaging MRI have offered invaluable insights into the macroscopic changes associated with SNHL such as cochlear morphology and structural abnormalities However these techniques lack the sensitivity to discern subtle alterations occurring at the microstructural level impeding a comprehensive understanding of the underlying pathophysiological processes
DTI-MRIs ability to capture subtle changes in tissue microstructure makes it an ideal candidate for probing the intricate auditory pathways affected by SNHL By quantifying the diffusion of water molecules along axonal pathways DTI-MRI can uncover alterations in the integrity of auditory neural connections which are often missed by conventional imaging methods Furthermore DTI-derived metrics such as fractional anisotropy FA axial diffusivity AD radial diffusivity RD and mean diffusivity MD offer quantitative measures to characterize the white matter integrity and myelination in auditory pathways
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None