Ignite Creation Date:
2024-06-16 @ 11:48 AM
Last Modification Date:
2024-10-26 @ 3:30 PM
Study NCT ID:
NCT06433843
Status:
COMPLETED
Last Update Posted:
2024-05-30
First Post:
2024-05-21
Brief Title:
FKBP5 Methylation and Childhood Emotional Abuse in Complex Posttraumatic Stress Disorder Investigating the Relationship and Its Predictive Role in Therapy Outcome
Sponsor:
University Hospital Tuebingen
Organization:
University Hospital Tuebingen
Study Overview
Official Title:
FKBP5 Methylation and Childhood Emotional Abuse in Complex Posttraumatic Stress Disorder Investigating the Relationship and Its Predictive Role in Therapy Outcome
Status:
COMPLETED
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The aim of this study is to investigate the role FKBP5 DNA methylation levels in patients suffering from complex posttraumatic stress disorder who participated in a 12-weeks disorder-specific DBT-PTSD inpatient treatment DNA methylation levels were measured before and after completing DBT-PTSD
Detailed Description:
Epigenetic modifications in the FKBP5 gene which is involved in regulating the stress response have been found to be associated with trauma-related mental disorders like posttraumatic stress disorder PTSD Previous research has suggested that FKBP5 may also be a predictor of therapy outcomes However there is limited evidence regarding its relationship with complex PTSD cPTSD This pilot study aimed to investigate the association between cPTSD and FKBP5 DNA methylation as well as its predictive role in therapy outcomes among patients undergoing Dialectical Behavior Therapy for PTSD DBT-PTSD a 12-week trauma-focused inpatient treatment program
29 patients with cPTSD who participated in the DBT-PTSD program were enrolled FKBP5 DNA methylation levels were measured at two CpG sites before treatment n25 and after completing DBT-PTSD n15 To assess the predictive value of FKBP5 DNA methylation we categorized the sample into responders and non-responders based on therapy outcome
29 patients with cPTSD who participated in the DBT-PTSD program were enrolled FKBP5 DNA methylation levels were measured at two CpG sites before treatment n25 and after completing DBT-PTSD n15 To assess the predictive value of FKBP5 DNA methylation we categorized the sample into responders and non-responders based on therapy outcome
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None