Ignite Creation Date:
2024-06-16 @ 11:48 AM
Last Modification Date:
2024-10-26 @ 3:30 PM
Study NCT ID:
NCT06426550
Status:
RECRUITING
Last Update Posted:
2024-05-23
First Post:
2024-05-17
Brief Title:
Clinical and Microbiological Evaluation of Laser Therapy in the Treatment of Periodontal Disease in Stages III and IV
Sponsor:
Universidade Federal Fluminense
Organization:
Universidade Federal Fluminense
Study Overview
Official Title:
Clinical and Microbiological Evaluation of Laser Therapy in the Treatment of Periodontal Disease in Stages III and IV
Status:
RECRUITING
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The aim of this clinical trial is to evaluate photodynamic therapy and photobiomodulation in the periodontitis treatment To evaluate the clinical and microbiological response of conventional periodontal treatment associated with photodynamic therapy and photobiomodulation with red or infrared laser
Participants will receive periodontal treatment carried out with the use 0005 methylene blue and laser therapy photodynamic therapy associated with conventional periodontal treatment as well as the use of photobiomodulation with red or infrared laser associated with conventional periodontal treatment in participants with periodontitis So twenty periodontitis patients will be selected and separated in two groups compared with placebo Clinical and microbiological parameters will be evaluated at baseline and 3 months after periodontal treatment plaque Index bleeding on probe probing depth gingival recession and clinical attachment level
Participants will receive periodontal treatment carried out with the use 0005 methylene blue and laser therapy photodynamic therapy associated with conventional periodontal treatment as well as the use of photobiomodulation with red or infrared laser associated with conventional periodontal treatment in participants with periodontitis So twenty periodontitis patients will be selected and separated in two groups compared with placebo Clinical and microbiological parameters will be evaluated at baseline and 3 months after periodontal treatment plaque Index bleeding on probe probing depth gingival recession and clinical attachment level
Detailed Description:
Periodontitis is a chronic inflammatory and multifactorial disease caused by an interaction between debiotic biofilm and its products and an exacerbated host response leading to the progressive destruction of the supporting periodontium bone cement and periodontal ligament causing loss of clinical attachment and radiographic bleeding on probing and periodontal pocket formation Periodontal disease has a high prevalence and is one of the main causes of edentulism with a great negative impact on chewing function aesthetics and quality of life related to oral health It is therefore considered a serious public health problem
Conventional periodontal therapy consists of scaling and root planing SRP and control of supragingival plaque but in some cases it has been shown to be ineffective in treating periodontitis especially in difficult to access areas such as furcations and deep pockets These cases benefit from adjuvant therapies such as laser therapy to help heal periodontal tissues reduce microorganisms and improve clinical parameters
Photobiomodulation and photodynamic therapy have been widely applied in the treatment of periodontal disease due to their clinical cellular and bactericidal effects When associated with conventional periodontal therapy its benefits increase promoting a significant reduction in probing depth number of deep pockets and bleeding Furthermore significant reduction of periodontopathogens and Candida albicans can be observed in the literature after photobiomodulation and photodynamic therapy
Despite the benefits found when different laser therapy protocols are used in periodontal treatment due to the lack of studies with high methodological quality and weak evidence in the existing literature more studies are needed to prove their effects establish appropriate protocols and evaluate the antimicrobial potential in periodontopathogens which remains debatable as recent systematic reviews point out
The direct benefits of this study are the treatment of periodontal disease for the participants and for the scientific community to indicate new forms of periodontal therapy using different protocols of laser therapy associated with periodontal instrumentation All tooth pocket sites in all groups will receive treatment
Conventional periodontal therapy consists of scaling and root planing SRP and control of supragingival plaque but in some cases it has been shown to be ineffective in treating periodontitis especially in difficult to access areas such as furcations and deep pockets These cases benefit from adjuvant therapies such as laser therapy to help heal periodontal tissues reduce microorganisms and improve clinical parameters
Photobiomodulation and photodynamic therapy have been widely applied in the treatment of periodontal disease due to their clinical cellular and bactericidal effects When associated with conventional periodontal therapy its benefits increase promoting a significant reduction in probing depth number of deep pockets and bleeding Furthermore significant reduction of periodontopathogens and Candida albicans can be observed in the literature after photobiomodulation and photodynamic therapy
Despite the benefits found when different laser therapy protocols are used in periodontal treatment due to the lack of studies with high methodological quality and weak evidence in the existing literature more studies are needed to prove their effects establish appropriate protocols and evaluate the antimicrobial potential in periodontopathogens which remains debatable as recent systematic reviews point out
The direct benefits of this study are the treatment of periodontal disease for the participants and for the scientific community to indicate new forms of periodontal therapy using different protocols of laser therapy associated with periodontal instrumentation All tooth pocket sites in all groups will receive treatment
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None