Ignite Creation Date:
2024-06-16 @ 11:48 AM
Last Modification Date:
2024-10-26 @ 3:30 PM
Study NCT ID:
NCT06427018
Status:
RECRUITING
Last Update Posted:
2024-05-30
First Post:
2024-05-19
Brief Title:
Expressions of Ezrin and Pip5k1α Proteins in Airway Smooth Muscle of Asthmatic Patients
Sponsor:
Lei-Miao Yin
Organization:
Shanghai University of Traditional Chinese Medicine
Study Overview
Official Title:
Assessing the Expressions of Ezrin Phosphorylated Ezrin and Pip5k1α in the Airway Smooth Muscle of Asthmatic Patient
Status:
RECRUITING
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Asthma a prevalent chronic respiratory affliction significantly impinges upon the quality of life for affected individuals Timely and appropriate diagnostic measures coupled with efficacious therapeutic interventions are paramount in mitigating exacerbations of symptoms and enhancing the life quality of patients
Ezrin plays an important role in maintaining cell morphology cell migration cell adhesion and polarisation but Ezrin expression in airway smooth muscle remains unclear
Pip5k1α is an important kinase involved in intracellular phosphatidylinositol signalling pathways that may be involved in smooth muscle contraction and diastole
Therefore further studies are necessary to elucidate the changes of Ezrin and Pip5k1α in patients with asthma to provide a basis for investigating alternative treatments for asthma
Ezrin plays an important role in maintaining cell morphology cell migration cell adhesion and polarisation but Ezrin expression in airway smooth muscle remains unclear
Pip5k1α is an important kinase involved in intracellular phosphatidylinositol signalling pathways that may be involved in smooth muscle contraction and diastole
Therefore further studies are necessary to elucidate the changes of Ezrin and Pip5k1α in patients with asthma to provide a basis for investigating alternative treatments for asthma
Detailed Description:
Asthma is a complex and heterogeneous disease with a combination of genetic and environmental multifactors which is mainly characterised by recurrent episodes of wheezing shortness of breath chest tightness and cough The nature of the pathology manifests itself as a chronic inflammatory disease with abnormal antigen presentation and T-cell activation and an imbalance of Th1Th2 cells leading to dysfunction of airway smooth muscle cells There is a lack of safe and effective medications against asthma for current treatment For example although glucocorticosteroids are the first-line drugs for asthma only 12 of patients are able to use them in accordance with medical advice β2 agonists are often used in combination with hormones but up to 55 of asthmatics still fail to get effective control of their symptoms Therefore the development of innovative drugs with new targets and mechanisms has become the trend of asthma drug development at home and abroad The discovery of new asthma targets will help to elucidate the asthma mechanism and solve a series of problems in clinical treatment
Ezrin is one of the major members of the Ezrin-Radixin-Moesin ERM family which plays an important role in the maintenance of cell morphology cell migration cell adhesion and polarisation Pip5k1α is an important kinase involved in the intracellular phosphatidylinositol signaling pathway which may be associated with the smooth muscle contraction and diastole related
In a previous study single-cell sequencing of lung tissue from asthmatic mice revealed that Ezrin and Pip5k1α were significantly increased in asthmatic airway smooth muscle cells In vitro cellular experiments suggested that Ezrin and Pip5k1α inhibition could inhibit airway smooth muscle cell contraction suggesting that inhibitors of both may provide a therapeutic advantage for reducing lung resistance in asthma Therefore further studies to elucidate the changes of Ezrin and Pip5k1α in asthma patients are warranted to provide a basis for the use of inhibitors of both as an alternative treatment for asthma
Ezrin is one of the major members of the Ezrin-Radixin-Moesin ERM family which plays an important role in the maintenance of cell morphology cell migration cell adhesion and polarisation Pip5k1α is an important kinase involved in the intracellular phosphatidylinositol signaling pathway which may be associated with the smooth muscle contraction and diastole related
In a previous study single-cell sequencing of lung tissue from asthmatic mice revealed that Ezrin and Pip5k1α were significantly increased in asthmatic airway smooth muscle cells In vitro cellular experiments suggested that Ezrin and Pip5k1α inhibition could inhibit airway smooth muscle cell contraction suggesting that inhibitors of both may provide a therapeutic advantage for reducing lung resistance in asthma Therefore further studies to elucidate the changes of Ezrin and Pip5k1α in asthma patients are warranted to provide a basis for the use of inhibitors of both as an alternative treatment for asthma
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None