Ignite Creation Date:
2024-06-16 @ 11:48 AM
Last Modification Date:
2024-10-26 @ 3:30 PM
Study NCT ID:
NCT06423846
Status:
COMPLETED
Last Update Posted:
2024-05-21
First Post:
2024-05-16
Brief Title:
Total Intravenous Anesthesia Versus Inhalation Anesthesia on Postoperative Liver Function
Sponsor:
Benha University
Organization:
Benha University
Study Overview
Official Title:
Comparison of Total Intravenous Anesthesia Versus Inhalation Anesthesia on Postoperative Liver Function in Patients With Non-Alcoholic Steatohepatitis Undergoing Laparoscopic Sleeve Gastrectomy A Randomized Clinical Trial
Status:
COMPLETED
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The pandemic of obesity has become a serious issue of public health worldwide as the size of the obese population has almost tripled over the last four decades and continues to riseزThe epidemic of obesity has led to a significant increase in the prevalence of non-alcoholic fatty liver disease NAFLD NAFLD is currently the most common chronic liver disease with an estimated global prevalence at 25-30 rising up to 90 in morbidly obese patients
Detailed Description:
Anesthesia and surgery may deteriorate liver function in patients with elevated liver enzyme levels therefore in these patients choosing anaesthetics with less hepatotoxicity may be important Halothane which is a typical inhalational anesthetic is known for its liver and kidney toxicity The latest anesthetic agents including sevoflurane and desflurane are associated with less hepatotoxicity although rare cases of acute liver injury have been reported with these agentsزPropofol 26-diisopropylphenol is an intravenous anesthetic Its pharmacokinetic profile makes it very suitable for total intravenous anesthesia TIVA and this is a widely used technique in many centers Its use results in a rapid onset and offset with fewer side effects including postoperative nausea and vomiting making it particularly favorable in the ambulatory setting
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None