Ignite Creation Date:
2024-06-16 @ 11:48 AM
Last Modification Date:
2024-10-26 @ 3:30 PM
Study NCT ID:
NCT06420401
Status:
RECRUITING
Last Update Posted:
2024-06-05
First Post:
2024-05-14
Brief Title:
Prebiotics and the Management of Hyperuricemia
Sponsor:
Sun Yat-sen University
Organization:
Sun Yat-sen University
Study Overview
Official Title:
Precision Treatment of Hyperuricemia Based on Different Combinations of Prebiotics
Status:
RECRUITING
Status Verified Date:
2024-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Hyperuricemia is a major risk factor for many chronic diesease Recently gut mcirobiota has been identified as a novel theraputic target for hyperuricemia Both annimal studies and pilot human trials have demonstrated that administration of prebiotics help delay the progression of hyperuricemia throuh several mechanisms This trial aims to examine its protective effects and potential mechanisms in clinical trials
Detailed Description:
Hyperuricemia is a major risk factor for many chronic diseases Recently dysbiosis of gut microbiota has been reported to play an important role in the pathogenesis of hyperuricemia Animal studies have demonstrated that administration of prebiotics help delay the progression of hyperuricemia through several mechanisms such as reduction in endotoxemia and enhanced production of short-chain fatty acids and hippuric acid
However whether administration of prebiotics also has a protective effect in subjects with hyperuricemia remain under-explored Moreover whether the original gut microbiota will influence the protective effect of prebiotics remains largely unknown
However whether administration of prebiotics also has a protective effect in subjects with hyperuricemia remain under-explored Moreover whether the original gut microbiota will influence the protective effect of prebiotics remains largely unknown
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None