Ignite Creation Date:
2024-06-16 @ 11:48 AM
Last Modification Date:
2024-10-26 @ 3:30 PM
Study NCT ID:
NCT06423807
Status:
COMPLETED
Last Update Posted:
2024-05-22
First Post:
2024-05-16
Brief Title:
Preoperative Ondansetron Lozenge for Prevention of Post-Spinal Shivering in Caesarean Section
Sponsor:
Tanta University
Organization:
Tanta University
Study Overview
Official Title:
Preoperative Ondansetron Lozenge for Prevention of Post-Spinal Shivering in Caesarean Section A Randomized Controlled Trial
Status:
COMPLETED
Status Verified Date:
2024-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The aim of this study is to estimate the role of ondansetron lozenge on prevention of post-spinal shivering in cesarean section
Detailed Description:
Spinal anesthesia SA is preferred for cesarean section CS compared with general anesthesiaGA because of several advantages including prevention of the potential risk of GA-related neurotoxicity
Post-spinal shivering PSS could be a provocative factor for postoperative pain and its appropriate treatment prevents non-thermoregulatory tremors Shivering also causes aggravating postoperative pain by stretching of sutures
Ondansetron is a selective antagonist for receptor 5-hydroxytryptamine 3 and is very effective in the prevention and treatment of shivering intra- and post-operation Ondansetron can affect the body temperature and shivering in rats since the balance of nor-epinephrine and 5-hydroxytryptamine 5-HT in the preoptic-anterior hypothalamus controls the temperature set point
Post-spinal shivering PSS could be a provocative factor for postoperative pain and its appropriate treatment prevents non-thermoregulatory tremors Shivering also causes aggravating postoperative pain by stretching of sutures
Ondansetron is a selective antagonist for receptor 5-hydroxytryptamine 3 and is very effective in the prevention and treatment of shivering intra- and post-operation Ondansetron can affect the body temperature and shivering in rats since the balance of nor-epinephrine and 5-hydroxytryptamine 5-HT in the preoptic-anterior hypothalamus controls the temperature set point
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None