Ignite Creation Date:
2024-06-16 @ 11:48 AM
Last Modification Date:
2024-10-26 @ 3:30 PM
Study NCT ID:
NCT06428968
Status:
RECRUITING
Last Update Posted:
2024-05-24
First Post:
2024-05-07
Brief Title:
Investigating the Insulin Resistance in Individuals With Type 2 Diabetes
Sponsor:
Central South University
Organization:
Central South University
Study Overview
Official Title:
Investigating the Central and Peripheral Insulin Resistance in Individuals With Type 2 Diabetes
Status:
RECRUITING
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Numerous studies have provided evidence of a correlation between Type 2 Diabetes Mellitus T2DM and cognitive dysfunction specifically in the realms of complex attention information processing and executive function These impairments have been observed in middle-aged and elderly individuals with T2DM with longer diabetes duration suboptimal glycemic control and the presence of diabetic complications being contributing factors Recent research in young adults and adolescents diagnosed with T2DM has revealed cognitive and brain structural alterations in this growing demographic suggesting that early disease mechanisms rather than solely vascular and age-related neurodegeneration contribute to pathogenesis However there remains uncertainty regarding the interplay between central and peripheral insulin resistance and its impact on cognitive dysfunction in individuals with T2DM This study aims to investigate central insulin resistance in T2DM elucidating its association with peripheral insulin resistance and the effects on cognitive impairments
Detailed Description:
Participants screened through inclusion and exclusion criteria will accept cross-sectional evaluation The information of demographic data medical history previous and current medication regimen details of complications and family history regarding metabolic diseases will be collected The assessments includes physical examination anthropometry blood testblood routine liver function renal function blood lipids fasting blood glucose serum insulinthyroid function and glycosylated hemoglobin A 1c MRI scan High-resolution T1-weighted Anatomical Images Diffusion Tensor Imaging Resting-state functional MRI and Arterial Spin Labeling and psychiatry scalesHamilton Depression Scale Young Mania Rating Scale and Self-reporting Inventory-90 cognitive function will be assessed by the Measurement and Treatment Research to Improve Cognition in SchizophreniaMATRICS Consensus Cognitive Battery biological samples also will be collected and stored to explore related mechanisms
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None