Ignite Creation Date:
2024-05-05 @ 7:04 PM
Last Modification Date:
2024-10-26 @ 9:43 AM
Study NCT ID:
NCT00605605
Status:
COMPLETED
Last Update Posted:
2008-01-31
First Post:
2008-01-18
Brief Title:
Vascular Endothelial Protection Effects of Dextromethorphan
Sponsor:
National Cheng-Kung University Hospital
Organization:
National Cheng-Kung University Hospital
Study Overview
Official Title:
Anti-Inflammation Vascular Endothelial Protection Effects of Dextromethorphan on Heavy Smoker
Status:
COMPLETED
Status Verified Date:
2008-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To test the hypothesis that DM could have anti-inflammatory effect and thus achieve vascular protection effect on heavy smokers
Detailed Description:
Dextromethorphan DM an ingredient widely used in antitussive remedies had been reported to reduce the inflammation-mediated degeneration of neurons We recently found that DM can prevent vascular remodeling and neuron injury in animal models of carotid ligation and cerebral ischemia injuries respectively It was believed that its action was through the anti-oxidant and NADPH pathway to protect brain cells However the mechanism and actual effect on human vascular protection remained unclear
To test the hypothesis that DM could have anti-inflammatory effect and thus achieve vascular protection effect on heavy smokers this prospective study will be conducted to treat subjects with heavy smoking history with DM or not and evaluate the anti-inflammatory and the improvement of endothelial function
To test the hypothesis that DM could have anti-inflammatory effect and thus achieve vascular protection effect on heavy smokers this prospective study will be conducted to treat subjects with heavy smoking history with DM or not and evaluate the anti-inflammatory and the improvement of endothelial function
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 91-B-FA09-2-4 grant number | None | None | None |