Ignite Creation Date:
2024-06-16 @ 11:47 AM
Last Modification Date:
2024-10-26 @ 3:30 PM
Study NCT ID:
NCT06420479
Status:
RECRUITING
Last Update Posted:
2024-06-17
First Post:
2024-05-14
Brief Title:
The Causal Effect of Bariatric Surgery on Cardiovascular Disease and Mortality
Sponsor:
Karolinska Institutet
Organization:
Karolinska Institutet
Study Overview
Official Title:
The Causal Effect of Bariatric Surgery on Cardiovascular Disease and Mortality
Status:
RECRUITING
Status Verified Date:
2024-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The association between weight and cardiovascular disease and mortality is well established however the causal effect of weight-loss in midlife on these outcomes is less clear Bariatric surgery results in substantial weight-loss and is an ideal candidate to study the causal effects of weight-loss The investigators propose a project that will use causal inference and machine learning methods to answer two important questions
1 Is bariatric surgery effective for reducing cardiovascular disease and mortality and if so for who
2 Which type of bariatric surgery gastric bypass or sleeve gastrectomy is most effective and for who The investigators will use data from various Swedish registers to identify individuals with obesity who are eligible for bariatric surgery We will then compare cardiovascular and mortality outcomes among those undergoing different types of bariatric surgery with those receiving non-surgical obesity management using causal inference methods The investigators will use causal forests and expert knowledge to estimate indiviual treatment effects and identify the groups of patients who benefit the most from these surgeries
1 Is bariatric surgery effective for reducing cardiovascular disease and mortality and if so for who
2 Which type of bariatric surgery gastric bypass or sleeve gastrectomy is most effective and for who The investigators will use data from various Swedish registers to identify individuals with obesity who are eligible for bariatric surgery We will then compare cardiovascular and mortality outcomes among those undergoing different types of bariatric surgery with those receiving non-surgical obesity management using causal inference methods The investigators will use causal forests and expert knowledge to estimate indiviual treatment effects and identify the groups of patients who benefit the most from these surgeries
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None