Ignite Creation Date:
2024-06-16 @ 11:47 AM
Last Modification Date:
2024-10-26 @ 3:30 PM
Study NCT ID:
NCT06425315
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-05-22
First Post:
2024-05-17
Brief Title:
Management of Malnutrition in Oncogeriatrics
Sponsor:
Hospices Civils de Lyon
Organization:
Hospices Civils de Lyon
Study Overview
Official Title:
Does Targeted Management of Undernutrition in Oncogeriatric Patients Aged 70 and Over Undergoing Cancer Treatment and Hospitalized From January 2022 to December 2023 Improve Their Nutritional and Functional Status
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
In France undernutrition affects almost three million people a third of whom are over 70 Diagnosing undernutrition earlier in the elderly aged 70 and over nd In fact 30 to 70 of hospitalized elderly patients suffer from protein-energy undernutrition denutrition_personne_agee_2007_-_recommandationspdf nd
The Nutricancer 2 study published in 2014 demonstrated that undernutrition is common among cancer patients Indeed 39 of patients suffer from undernutrition and its prevalence depends on the type of cancer with a predominance of esophagus stomach and pancreas 60 to 66 colonrectum ovaryuterus and lung 39 to 45 hematological malignancies 34 as well as prostate and breast 13 to 20 Hébuterne et al 2014 Moreover over the past 30 years undernutrition has been observed in 30 to 50 of the population at the time of diagnosis and before the start of cancer treatment Boranian et al n d
Undernutrition is often associated with several terms such as malnutrition anorexia sarcopenia or cachexia which refer to geriatric or metabolic syndromes of multifactorial origin that sometimes overlap and are often observed in cancer patients Cancer cachexia is a metabolic syndrome associated with undernutrition of multifactorial origin Boranian et al nd Its prevalence is around 50 to 80 in cancer patients and is an independent indicator of morbidity and mortality in this population Nicolini et al 2013
Undernutrition is a major health issue in elderly cancer patients It is therefore crucial to diagnose it early given its high prevalence in this population and the serious complications it can lead to In 2021 the HAS updated its recommendations on the diagnosis of undernutrition in the elderly The diagnosis of severe undernutrition is based on several criteria including serum albumin levels This is a commonly used marker of nutritional status especially in patients with involuntary weight loss However it is important to note that hypoalbuminemia can be observed in many pathological conditions including inflammatory syndromes common in cancer Therefore interpretation of albuminemia results must take into account the patients inflammatory status assessed by C-reactive protein This analysis makes it possible to distinguish undernutrition due to insufficient food intake from that associated with an inflammatory syndrome and hypercatabolism Patry Raynaud-Simon 2010
The Nutricancer 2 study published in 2014 demonstrated that undernutrition is common among cancer patients Indeed 39 of patients suffer from undernutrition and its prevalence depends on the type of cancer with a predominance of esophagus stomach and pancreas 60 to 66 colonrectum ovaryuterus and lung 39 to 45 hematological malignancies 34 as well as prostate and breast 13 to 20 Hébuterne et al 2014 Moreover over the past 30 years undernutrition has been observed in 30 to 50 of the population at the time of diagnosis and before the start of cancer treatment Boranian et al n d
Undernutrition is often associated with several terms such as malnutrition anorexia sarcopenia or cachexia which refer to geriatric or metabolic syndromes of multifactorial origin that sometimes overlap and are often observed in cancer patients Cancer cachexia is a metabolic syndrome associated with undernutrition of multifactorial origin Boranian et al nd Its prevalence is around 50 to 80 in cancer patients and is an independent indicator of morbidity and mortality in this population Nicolini et al 2013
Undernutrition is a major health issue in elderly cancer patients It is therefore crucial to diagnose it early given its high prevalence in this population and the serious complications it can lead to In 2021 the HAS updated its recommendations on the diagnosis of undernutrition in the elderly The diagnosis of severe undernutrition is based on several criteria including serum albumin levels This is a commonly used marker of nutritional status especially in patients with involuntary weight loss However it is important to note that hypoalbuminemia can be observed in many pathological conditions including inflammatory syndromes common in cancer Therefore interpretation of albuminemia results must take into account the patients inflammatory status assessed by C-reactive protein This analysis makes it possible to distinguish undernutrition due to insufficient food intake from that associated with an inflammatory syndrome and hypercatabolism Patry Raynaud-Simon 2010
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None