Ignite Creation Date:
2024-05-19 @ 5:35 PM
Last Modification Date:
2024-10-26 @ 3:29 PM
Study NCT ID:
NCT06418399
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-05-17
First Post:
2024-05-13
Brief Title:
The Role of Central Sensitization in Pain Functionality and Quality of Life in Cancer Patients
Sponsor:
Marmara University
Organization:
Marmara University
Study Overview
Official Title:
The Role of Central Sensitization in Pain Functionality and Quality of Life in Cancer Patients
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Pain is one of the most important and challenging symptoms in cancer patients Depending on the stage of cancer approximately 40 to 70 of patients complain of pain With the increasing lifespan of cancer patients due to developing treatments pain palliation has become even more crucial to improve their quality of life Cancer-related pain can develop through multiple mechanisms such as the tumor itself metastasis or the methods used in treatment The type of pain can be nociceptive neuropathic or mixed
Central sensitization refers to the increased response of central nervous system nociceptive neurons to normal or subthreshold stimuli Recently central sensitization CS has been recognized as a potential pathophysiological mechanism underlying a group of chronic pain diseases such as fibromyalgia temporomandibular joint disorder irritable bowel syndrome interstitial cystitis tension-type headache and chronic low back pain Since pain perception varies from person to person physicians should assess the character of pain thoroughly and not rely solely on peripheral pain treatment in cases with a component of central sensitization The lack of evaluation of the extent to which central sensitization affects patients and the failure to fully determine the factors influencing it appear to be clinical limitations for now
There are studies suggesting that central sensitization may be a significant factor in chronic refractory pain in cancer patients indicating the need for consideration of alternative options to classical treatments To the best of our knowledge no study has been conducted in Turkey to investigate the frequency of central sensitization and its impact on treatment outcomes in chronic cancer pain patients visiting outpatient clinics The aim of this study is to investigate the frequency of central sensitization and its effect on pain and quality of life in chronic cancer pain patients attending algology clinics in multiple centers in Turkey
Central sensitization refers to the increased response of central nervous system nociceptive neurons to normal or subthreshold stimuli Recently central sensitization CS has been recognized as a potential pathophysiological mechanism underlying a group of chronic pain diseases such as fibromyalgia temporomandibular joint disorder irritable bowel syndrome interstitial cystitis tension-type headache and chronic low back pain Since pain perception varies from person to person physicians should assess the character of pain thoroughly and not rely solely on peripheral pain treatment in cases with a component of central sensitization The lack of evaluation of the extent to which central sensitization affects patients and the failure to fully determine the factors influencing it appear to be clinical limitations for now
There are studies suggesting that central sensitization may be a significant factor in chronic refractory pain in cancer patients indicating the need for consideration of alternative options to classical treatments To the best of our knowledge no study has been conducted in Turkey to investigate the frequency of central sensitization and its impact on treatment outcomes in chronic cancer pain patients visiting outpatient clinics The aim of this study is to investigate the frequency of central sensitization and its effect on pain and quality of life in chronic cancer pain patients attending algology clinics in multiple centers in Turkey
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None