Ignite Creation Date:
2024-05-19 @ 5:35 PM
Last Modification Date:
2024-10-26 @ 3:29 PM
Study NCT ID:
NCT06411340
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-05-14
First Post:
2024-05-08
Brief Title:
Inflammation in Acute Cardiovascular Diseases - the CArdiovascular Inflammation Registry CAIR
Sponsor:
Kings College London
Organization:
Kings College London
Study Overview
Official Title:
An Observational-based Registry of Routinely Collected Clinical Parameters to Study Inflammation in Acute Cardiovascular Diseases - the CArdiovascular Inflammation Registry
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
CAIR
Brief Summary:
Following acute cardiovascular injury inflammation is vital to activate reparative mechanisms However there is compelling evidence implicating excessive inflammation and dysregulated resolution in fibrosis ventricular remodelling and heart failure HF Recently the anti-inflammatory agent colchicine reduced cardiovascular events after myocardial infarction MI compared to placebo indicating that targeting inflammation in acute cardiovascular conditions is feasible Several acute cardiovascular conditions are characterised by inflammation including myocarditis MI and acute heart failure However there is large variability in definition epidemiology clinical presentation pathophysiology and natural history of acute inflammatory cardiovascular diseases This relates in part to the difficulty in performing adequately powered studies Clinical studies that include sufficient patients and extended observation periods are necessary to address some of these knowledge gaps This registry aims to collate routinely collected clinical data on patients with acute cardiovascular diseases characterised by inflammation in an observational-based registry By doing so the investigators hope to understand the contribution of inflammation to the pathophysiology of acute cardiovascular disease improve risk stratification and identify potential novel therapeutic targets
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None