Ignite Creation Date:
2024-05-19 @ 5:34 PM
Last Modification Date:
2024-10-26 @ 3:30 PM
Study NCT ID:
NCT06419244
Status:
RECRUITING
Last Update Posted:
2024-05-17
First Post:
2024-03-20
Brief Title:
Myosteatosis in Oeso-gastric Cancer Clinical Impacts
Sponsor:
Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Organization:
Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Study Overview
Official Title:
Myosteatosis in Oeso-gastric Cancer Clinical Impacts
Status:
RECRUITING
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The aim of this project is to study the presence of cancer-associated adipocytes in oesogastric cancers and their possible links with myosteatosis This research project has a retrospective component the aim of which is to analyse the body component based on imaging in patients with oesogastric neoplasia in order to determine the incidence of myosteatosis and to study the relationship with oncological and prognostic data The second part of the project is prospective and will collect biological material skeletal muscle adipose tissue tumour blood for histological molecular and genomic analyses and will analyse muscle function in patients with oesogastric cancer It will address the role of adipocytes in the tumour microenvironment of oesogastric cancer focusing on their interactions with the observed muscle myosteatosis and prognosis In the future it will help to identify signalling pathways targets and patients who could benefit from appropriate treatment
Detailed Description:
Oesophageal and gastric cancer pose a significant challenge to caregivers both in terms of the complexity of its presentation and its treatment At diagnosis patients often present with malnutrition associated with sarcopenia which has a significant impact on morbidity and mortality Although loss of muscle mass has received much attention in cancer muscle quality particularly the accumulation of fat in muscle named myosteatosis may be considered as a better predictor of a patients physical condition and ability to recover from cancer treatments Studying the tumor microenvironment is essential to understanding the mechanisms underlying disease progression Cancer-associated adipocytes CAA a major component of this tumor microenvironment provide an interface for dialogue with the tumor through the secretion of pro-inflammatory cytokines metalloproteases and the release of free fatty acids They have been described as capable of stimulating tumor progression particularly in breast cancer However their presence in oesogastric cancer and possible links with myosteatosis have not been described
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None