Ignite Creation Date:
2024-05-19 @ 5:34 PM
Last Modification Date:
2024-10-26 @ 3:29 PM
Study NCT ID:
NCT06413160
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-05-14
First Post:
2024-05-06
Brief Title:
The Cardiovascular-Renal-Metabolic CRM Syndrome Survey in Jordan
Sponsor:
Jordan Collaborating Cardiology Group
Organization:
Jordan Collaborating Cardiology Group
Study Overview
Official Title:
The Cardiovascular-Renal-Metabolic CRM Syndrome Survey in Jordan
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
JoCRMSSurvey
Brief Summary:
Cardiovascular-renal-metabolic CRM syndrome is defined as a systemic disorder with a collection of related signs and symptoms attributable to the coexistence of multiple cardiovascular renal and metabolic disease with a common underlying pathophysiology in one individual Surveying this syndrome in a large population in Jordan aims at studying the risk factors components and stages of the syndrome thus helping early screening diagnosing and treating disease and its risk factors
Detailed Description:
Cardiovascular-renal-metabolic CRM syndrome is defined as a systemic disorder with a collection of related signs and symptoms attributable to the coexistence of multiple cardiovascular renal and metabolic disease with a common underlying pathophysiology in one individual
CRM syndrome reflects the intersection of cardiovascular disease with chronic kidney disease CKD and metabolic disease and risk factors RF A critical combination of these diseases and their risk factors in the same individual has a profound impact on quality of life and overall mortality The clinical implications of the presence of CRM are significant with premature morbidity and mortality multiple organ-system disease and high health care budgets mainly driven by the burden of cardiovascular disease CVD
There are high prevalence rates of all components of CRM and its RF on a global level and in the Middle East Of note is the high prevalence of CV in the young smoking diabetes mellitus obesity and dyslipidemia
The current study will evaluate the prevalence of components and RF of CRM disease in a large population in North central and South of Jordan
In the Middle East no systematic study has evaluated the definition of CRM definition of its stages and prevalence of its RF and its relation to the coexisting social determinants of health
The study will provide new and contemporary knowledge on the definition staging and comprehensive approaches to care for patients with CRM and subsequently exploring opportunities for prevention and care optimization by life style modification and pharmacotherapy
There are different aspects that explain the interaction between the components of CRM A The bidirectional association between the heart failure and the kidneys cardiorenal syndrome in addition to the risk of CAD in patients with CKD B adipose tissue link to atherosclerosis mediated by inflammation insulin resistance and endothelial dysfunction and risk for DM C DM link to CVD heart failure and kidney dysfunction and many other links as well
Screening for CRM is an important pillar in promoting health in every community The CRM staging system facilitates identifying individuals at progressive levels of severity starting from the preclinical phase to delay or avoid the onset of clinical CVD and CKD To appropriately find individuals at stage 0 ie asymptomatic stage it is important to undertake active screening within the population
CRM syndrome reflects the intersection of cardiovascular disease with chronic kidney disease CKD and metabolic disease and risk factors RF A critical combination of these diseases and their risk factors in the same individual has a profound impact on quality of life and overall mortality The clinical implications of the presence of CRM are significant with premature morbidity and mortality multiple organ-system disease and high health care budgets mainly driven by the burden of cardiovascular disease CVD
There are high prevalence rates of all components of CRM and its RF on a global level and in the Middle East Of note is the high prevalence of CV in the young smoking diabetes mellitus obesity and dyslipidemia
The current study will evaluate the prevalence of components and RF of CRM disease in a large population in North central and South of Jordan
In the Middle East no systematic study has evaluated the definition of CRM definition of its stages and prevalence of its RF and its relation to the coexisting social determinants of health
The study will provide new and contemporary knowledge on the definition staging and comprehensive approaches to care for patients with CRM and subsequently exploring opportunities for prevention and care optimization by life style modification and pharmacotherapy
There are different aspects that explain the interaction between the components of CRM A The bidirectional association between the heart failure and the kidneys cardiorenal syndrome in addition to the risk of CAD in patients with CKD B adipose tissue link to atherosclerosis mediated by inflammation insulin resistance and endothelial dysfunction and risk for DM C DM link to CVD heart failure and kidney dysfunction and many other links as well
Screening for CRM is an important pillar in promoting health in every community The CRM staging system facilitates identifying individuals at progressive levels of severity starting from the preclinical phase to delay or avoid the onset of clinical CVD and CKD To appropriately find individuals at stage 0 ie asymptomatic stage it is important to undertake active screening within the population
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None