Ignite Creation Date:
2024-05-19 @ 5:34 PM
Last Modification Date:
2024-10-26 @ 3:29 PM
Study NCT ID:
NCT06410222
Status:
ENROLLING_BY_INVITATION
Last Update Posted:
2024-05-13
First Post:
2024-03-27
Brief Title:
Predictive Models for the Treatment of Recurrent Herpes Zoster Neuralgia Following Spinal Cord Electrical Stimulation
Sponsor:
Feng Gao
Organization:
Tongji Hospital
Study Overview
Official Title:
Risk Factor Analysis and Predictive Models for the Treatment of Recurrent Herpes Zoster Neuralgia Following Short-course Spinal Cord Electrical Stimulation a Multicenter Retrospective Observational Study
Status:
ENROLLING_BY_INVITATION
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Shingles is a neuropathic disease caused by varicella-herpes virusVZV invading nerves and accompanying painCurrently the treatment of postherpetic neuralgia PHN includes medication and minimally invasive interventional therapyIn patients with herpes zoster neuralgia treated with spinal cord stimulation SCS some patients have satisfactory pain relief after surgery but some patients have pain symptoms again some time after surgery The reason for this difference in treatment effect is not clear
Detailed Description:
Shingles is a neuropathic disease caused by varicella-herpes virusVZV invading nerves and accompanying pain About 351000 people suffer from shingles every year in the world and 29581000 people over the age of 50 in China suffer from shingles every year with an annual growth rate of 2550 If acute herpes zoster can not be treated effectively it will be transformed into postherpetic neuralgia PHN patients will suffer long-term knife needle burning pain as well as hyperalgesia touch induced pain and skin paresthesia which seriously affect the daily life of patients It also causes a huge social and economic burdenCurrently the treatment of postherpetic neuralgia PHN includes medication and minimally invasive interventional therapy The European Neurological Association has proposed guidelines for first - and second-line drug treatment of herpes zoster neuralgia with level A evidence At the same time some patients are relieved by interventional therapy such as injection therapy local injection peripheral nerve block stellar ganglion block nerve stimulation therapy percutaneous electrical nerve stimulation peripheral nerve stimulation pulsed radiofrequency spinal cord stimulation SCS and spinal dorsal horn ganglion destruction
In 1976 spinal cord stimulation SCS was first used to treat patients with nociceptive pain It is to place the stimulation electrode around the diseased nerve for a certain time frequency and voltage adjustment so as to relieve pain At present spinal cord stimulation SCS has been widely used and studied in the treatment of postherpetic neuralgia PHN at home and abroad and its mechanism of action may be related to the gate control theory of pain in the dorsal horn of the spinal cord α fiber can inhibit the pain signal transmitted by C fiber and spinal cord stimulation SCS may regulate the transmission of pain signal through this mechanism At the same time spinal cord stimulation SCS can also affect the levels of gamma-aminobutyric acid and adenosine in the dorsal horn thereby reducing neuropathic painIn patients with herpes zoster neuralgia treated with spinal cord stimulation SCS some patients have satisfactory pain relief after surgery but some patients have pain symptoms again some time after surgery The reason for this difference in treatment effect is not clear Therefore this study intends to retrospectively analyze the clinical data of patients with and the risk factors for recurrence after treatment and then construct a prognostic prediction model to provide evidence and reference for clinical treatment of postherpetic neuralgia PHN
In 1976 spinal cord stimulation SCS was first used to treat patients with nociceptive pain It is to place the stimulation electrode around the diseased nerve for a certain time frequency and voltage adjustment so as to relieve pain At present spinal cord stimulation SCS has been widely used and studied in the treatment of postherpetic neuralgia PHN at home and abroad and its mechanism of action may be related to the gate control theory of pain in the dorsal horn of the spinal cord α fiber can inhibit the pain signal transmitted by C fiber and spinal cord stimulation SCS may regulate the transmission of pain signal through this mechanism At the same time spinal cord stimulation SCS can also affect the levels of gamma-aminobutyric acid and adenosine in the dorsal horn thereby reducing neuropathic painIn patients with herpes zoster neuralgia treated with spinal cord stimulation SCS some patients have satisfactory pain relief after surgery but some patients have pain symptoms again some time after surgery The reason for this difference in treatment effect is not clear Therefore this study intends to retrospectively analyze the clinical data of patients with and the risk factors for recurrence after treatment and then construct a prognostic prediction model to provide evidence and reference for clinical treatment of postherpetic neuralgia PHN
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None