Ignite Creation Date:
2024-05-19 @ 5:34 PM
Last Modification Date:
2024-10-26 @ 3:29 PM
Study NCT ID:
NCT06410261
Status:
RECRUITING
Last Update Posted:
2024-05-13
First Post:
2024-05-07
Brief Title:
Exercise Rehabilitation Program in MS Who Use Wheelchairs as a Primary Mobility Device
Sponsor:
University of Illinois at Chicago
Organization:
University of Illinois at Chicago
Study Overview
Official Title:
Randomized Pilot Study Evaluating the Effect of a 6-Month Exercise Rehabilitation Program on Physical and Cognitive Function in Persons With MS Who Use Wheelchairs as a Primary Mobility Device
Status:
RECRUITING
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
MSGH
Brief Summary:
Approximately 50 of people with multiple sclerosis MS use a wheelchair within 30 years of the initial diagnosis Wheelchair use in MS is often associated with fatigue as a consequence of muscle weakness Indeed fatigue a prevalent consequence of MS often becomes debilitating and exhausts energetic resources when carrying-out tasks of daily life andor interacting with the community as these require ambulatory mobility This experience of excessive fatigue has its roots in muscle weakness and results in reliance on a wheelchair for mobility and the dependency on a wheelchair may further reduce muscular strength particularly of the lower extremities We propose that wheelchair users with MS can increase muscular strength through a personalized exercise rehabilitation and this in turn will improve ambulatory performance and possibly reduce fatigue To date no research has examined the effects of this specific exercise rehabilitation program GH method on physical function and other disease-related outcomes in persons with MS who use wheelchairs as a primary mobility device
Detailed Description:
To date there is a dearth of clinical trials examining exercise programs targeting wheelchair users with MS but exercise programs are ideally suited for targeting the underlying causes of wheelchair use in this population namely reduced lower extremity strength that manifests as excessive fatigue when undertaking tasks of daily life andor interacting with the community We propose examining a novel and highly relevant exercise rehabilitation program GH method on physical function and other disease-related outcomes in persons with MS who use wheelchairs as a primary mobility device
There are no relevant preliminary data in wheelchair users with MS but the GH method has been successfully applied in other chronic disabling diseases such as chronic kidney disease CKD The data from our previous and ongoing application of GH in CKD has supported improvements in a range of outcomes from physical frailty through quality of life
This proposed research will test the effects of a 6-month exercise rehabilitation program on physical function self-reported health-related outcomes and cognitive function in persons with MS who use wheelchairs as a primary mobility device in the community but who are still ambulatory These findings may guide researchers clinicians and exercise specialists in the advancement of future interventions for improving the lives of persons from this segment of the population with MS
There are no relevant preliminary data in wheelchair users with MS but the GH method has been successfully applied in other chronic disabling diseases such as chronic kidney disease CKD The data from our previous and ongoing application of GH in CKD has supported improvements in a range of outcomes from physical frailty through quality of life
This proposed research will test the effects of a 6-month exercise rehabilitation program on physical function self-reported health-related outcomes and cognitive function in persons with MS who use wheelchairs as a primary mobility device in the community but who are still ambulatory These findings may guide researchers clinicians and exercise specialists in the advancement of future interventions for improving the lives of persons from this segment of the population with MS
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None