Ignite Creation Date:
2024-05-19 @ 5:33 PM
Last Modification Date:
2025-12-17 @ 7:22 PM
Study NCT ID:
NCT06417086
Status:
None
Last Update Posted:
2025-05-21 00:00:00
First Post:
2024-05-12 00:00:00
Brief Title:
Clinical Evaluation of Acupuncture Treatment on Alzheimer's Disease in APOE e4 Carriers and Non-Carriers
Sponsor:
Shanghai University of Traditional Chinese Medicine
Organization:
Shanghai University of Traditional Chinese Medicine
Study Overview
Official Title:
Clinical Evaluation of Acupuncture Treatment on Alzheimer's Disease in APOE e4 Carriers and Non-Carriers: A Randomized Controlled Trial
Status:
None
Status Verified Date:
2025-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This is a two-centre randomized controlled trial. A total of 176 participants with mild-to-moderate Alzheimer's disease, 88 APOE e4 carriers and 88 non-carriers, will be randomly assigned to either an acupuncture combined with donepezil group or a sham acupuncture combined with donepezil group with a ratio of 1:1. The main acupoints are DU 24, EX-HN 3, DU 20, EX-HN 1, GB 12, HT 7, KI 6, GB39. There will be 12 weeks of 3-session treatment for each participant, and a 52-week follow-up in total. The primary outcome is the change and effective rate from baseline in the ADAS-cog score measured at Week 12.
Detailed Description:
This is a two-centre randomized controlled trial A total of 176 participants with mild-to-moderate Alzheimers disease 88 APOE e4 carriers and 88 non-carriers will be randomly assigned to either an acupuncture combined with donepezil group or a sham acupuncture combined with donepezil group with a ratio of 11 The main acupoints are DU 24 EX-HN 3 DU 20 EX-HN 1 GB 12 HT 7 KI 6 GB39 There will be 12 weeks of 3-session treatment for each participant and a 52-week follow-up in total The primary outcome is the change and effective rate from baseline in the ADAS-cog score measured at Week 12
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None