Ignite Creation Date:
2024-05-05 @ 11:21 AM
Last Modification Date:
2024-10-26 @ 9:02 AM
Study NCT ID:
NCT00001921
Status:
COMPLETED
Last Update Posted:
2019-12-17
First Post:
1999-11-03
Brief Title:
Electrophysiology and Blood Flow in Patients With Schizophrenia and Their Siblings
Sponsor:
National Institute of Mental Health NIMH
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Integrating EEGMEG and fMRI Activity Correlation Between Frontal and Temporal Lobe Structures in Schizophrenic Patients Their Siblings and Unrelated Normal Volunteers
Status:
COMPLETED
Status Verified Date:
2018-06-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will explore how the brain works during memory testing in an effort to understand why some patients with schizophrenia have memory difficulties
Patients with schizophrenia and their unaffected family members are eligible for this study Studying family members may help identify the genes related to the memory deficit in schizophrenia Normal volunteers will also be studied
Normal volunteers patients with schizophrenia and their family members interested in participating in this study will be screened with a complete medical examination and psychiatric assessment and performance of simple tasks Study participants will be shown numbers on a screen and asked to recall them after a brief period This will be done during electroencephalographic EEG recording in which electrodes attached to the scalp measure the brain s electrical activity The same test will be repeated while the patient has magnetic resonance imaging of the brain The combined MRI and EEG testing will permit better localization of the brain s electrical activity
Patients with schizophrenia and their unaffected family members are eligible for this study Studying family members may help identify the genes related to the memory deficit in schizophrenia Normal volunteers will also be studied
Normal volunteers patients with schizophrenia and their family members interested in participating in this study will be screened with a complete medical examination and psychiatric assessment and performance of simple tasks Study participants will be shown numbers on a screen and asked to recall them after a brief period This will be done during electroencephalographic EEG recording in which electrodes attached to the scalp measure the brain s electrical activity The same test will be repeated while the patient has magnetic resonance imaging of the brain The combined MRI and EEG testing will permit better localization of the brain s electrical activity
Detailed Description:
It is the aim of this study to investigate the functional activation and coupling between brain regions in normals patients with schizophrenia and unaffected family members We will perform electrophysiological recordings MEG EEG during cognitive activation Continuous Performance Task Sternberg paradigm working memory We will focus on the investigation of oscillatory brain activity as this is considered to be crucial for information processing related to neuronal integration The measurements will be closely adapted to equivalent fMRI-measurements presented as an independent protocol 00-M-0085 The combination of both methods will help to improve activity source localization MEGEEG and correlation of this activity between different parts of the brain In addition local activity patterns fMRI can be better characterized in the time domain tonic versus phasic BOLD-activation We will address whether cognitive activation goes along with an increase or decrease of correlation between regional brain areas In this context we will investigate whether this correlated activation pattern is different in schizophrenics and unaffected siblings when compared with normals The study is integrated with the schizophrenia-sibling study 95-M-0150 Siblings of schizophrenic patients are investigated in order to achieve a better understanding of the genetic determination of schizophrenia-related pathophysiology
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 99-M-0172 | None | None | None |