Ignite Creation Date:
2024-05-11 @ 8:31 AM
Last Modification Date:
2024-10-26 @ 3:29 PM
Study NCT ID:
NCT06408454
Status:
COMPLETED
Last Update Posted:
2024-05-10
First Post:
2024-04-15
Brief Title:
Interleukin- 17 IL-17 Bcl-3 and NF-kappa-B Inhibitor Zeta IκBζ Expression Levels in the Psoriasis Patients
Sponsor:
Kahramanmaras Sutcu Imam University
Organization:
Kahramanmaras Sutcu Imam University
Study Overview
Official Title:
Determination of IL-17 Bcl-3 AND IκBζ Expression Levels in the Gingival Crevicular Fluid of Psoriasis Patients
Status:
COMPLETED
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study aimed to compare the levels of IL-17 interleukin- 17 Bcl-3 B-cell lymphoma 3-encoded protein and IκBζ NF-kappa-B inhibitor zeta in the gingival crevicular fluid of psoriatic and healthy individuals and the clinical parameters such as periodontal health gingival index plaque index and mobility using periotest devicein the patient and control groups
Detailed Description:
Patient selection
Ten patients previously diagnosed with psoriasis who visited the Van 100 Yıl University Faculty of Dentistry Oral and Maxillofacial Radiology dental clinic were included in the study Non-psoriasis individuals were selected from volunteer patients attending the same dental clinic
Clinical measurements
A periodontist conducted the periodontal evaluation which included a comprehensive assessment of clinical periodontal status a full mouth manual periodontal charting measurement of probing depth clinical attachment level bleeding on probing and evaluation of mobility using a periotest device Additionally information regarding the patients smoking status frequency of smoking and oral hygiene habits was obtained
Gingival crevicular fluid GCF collection
Samples were taken from two mandibular molar teeth Before sampling the sites were isolated with cotton rolls and then carefully dried with an air syringe to avoid saliva contamination GCF was collected using sterile periodontal strips by gently inserting them into the gingival sulcus or pocket until slight resistance was noticed After 30 s the strips were collected into sterile tubes and immediately transported to the laboratory for storage -40 C and posterior analysis
Ten patients previously diagnosed with psoriasis who visited the Van 100 Yıl University Faculty of Dentistry Oral and Maxillofacial Radiology dental clinic were included in the study Non-psoriasis individuals were selected from volunteer patients attending the same dental clinic
Clinical measurements
A periodontist conducted the periodontal evaluation which included a comprehensive assessment of clinical periodontal status a full mouth manual periodontal charting measurement of probing depth clinical attachment level bleeding on probing and evaluation of mobility using a periotest device Additionally information regarding the patients smoking status frequency of smoking and oral hygiene habits was obtained
Gingival crevicular fluid GCF collection
Samples were taken from two mandibular molar teeth Before sampling the sites were isolated with cotton rolls and then carefully dried with an air syringe to avoid saliva contamination GCF was collected using sterile periodontal strips by gently inserting them into the gingival sulcus or pocket until slight resistance was noticed After 30 s the strips were collected into sterile tubes and immediately transported to the laboratory for storage -40 C and posterior analysis
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None