Ignite Creation Date:
2024-05-11 @ 8:31 AM
Last Modification Date:
2024-10-26 @ 3:29 PM
Study NCT ID:
NCT06405477
Status:
RECRUITING
Last Update Posted:
2024-05-08
First Post:
2024-04-26
Brief Title:
EFFECTS OF L-ARGININE SUPPLEMENTATION ON THE RECOVERY OF CARDIORESPIRATORY PARAMETERS AFTER SUBMAXIMAL EXERCISE TEST
Sponsor:
Universidade Estadual Paulista Júlio de Mesquita Filho
Organization:
Universidade Estadual Paulista Júlio de Mesquita Filho
Study Overview
Official Title:
EFFECTS OF L-ARGININE SUPPLEMENTATION ON THE RECOVERY OF CARDIORESPIRATORY PARAMETERS AFTER SUBMAXIMAL EXERCISE TEST
Status:
RECRUITING
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
L-Arginine is an amino acid capable of stimulating the production of nitric oxide NO metabolites NO is responsible for several important activities of the body such as helping to regulate vasodilation blood flow mitochondrial respiration platelet function and increasing growth hormone levels but the effects on the recovery of cardiorespiratory parameters after exercise testing maximum need to be clarified
Detailed Description:
The protocols will be carried out at the Stress Physiology Laboratory of the Faculty of Science and Technology UNESP-Presidente Prudente The execution time of the protocols will be between 500 pm and 900 pm to standardize the circadian influence on the evaluated parameters the environmental climate will be controlled with a temperature between 23ºC and 24 ºC and humidity between 60 and 70 Volunteers will be instructed not to drink alcoholic or caffeine-based drinks for 12 hours before all protocols to consume a light meal and 500 ml of water two hours before and to avoid vigorous physical exertion the day before The experimental procedure will be divided into two stages all carried out on a treadmill with a minimum interval of 48 hours between them in order to allow adequate recovery Before the start of the first stage of the protocols anthropometric measurements will be taken body weight using a digital scale and height using a stadiometer
Before the beginning of each stage a Polar RS800CX heart rate monitor will be placed to record the heart rate HR and its variability remaining until the end of each protocol Afterwards he will sit for 60 minutes of initial rest and HR Systolic Blood Pressure SBP Diastolic Blood Pressure DBP oxygen saturation SpO2 and Heart Rate Variability HRV will be measured After these measurements volunteers will go to the second phase
Placebo protocol PP consisting of the prior consumption of 3g of placebo starch and subsequently resting for 60 minutes sitting then a submaximal exercise test on an ergometric treadmill or
Arginine PA experimental protocol in this stage volunteers will perform activities similar to the PC but they previously consumed 3g of L-arginine 60 minutes before the submaximal test and then
Perform physical exercise on a treadmill with a 1 incline for the first 3 minutes to warm up at a speed of 5kmh followed by load increments of 1kmh every 2 minutes until reaching 80 of the maximum HR estimated by age 208- 07age with the same inclination At the end of the activity you will remain lying down in a calm environment where HR SBP DBP Spo2 and HRV will be monitored for another 20 minutes in the 1st 3rd 5th 7th 10th and 20th minute
Before the beginning of each stage a Polar RS800CX heart rate monitor will be placed to record the heart rate HR and its variability remaining until the end of each protocol Afterwards he will sit for 60 minutes of initial rest and HR Systolic Blood Pressure SBP Diastolic Blood Pressure DBP oxygen saturation SpO2 and Heart Rate Variability HRV will be measured After these measurements volunteers will go to the second phase
Placebo protocol PP consisting of the prior consumption of 3g of placebo starch and subsequently resting for 60 minutes sitting then a submaximal exercise test on an ergometric treadmill or
Arginine PA experimental protocol in this stage volunteers will perform activities similar to the PC but they previously consumed 3g of L-arginine 60 minutes before the submaximal test and then
Perform physical exercise on a treadmill with a 1 incline for the first 3 minutes to warm up at a speed of 5kmh followed by load increments of 1kmh every 2 minutes until reaching 80 of the maximum HR estimated by age 208- 07age with the same inclination At the end of the activity you will remain lying down in a calm environment where HR SBP DBP Spo2 and HRV will be monitored for another 20 minutes in the 1st 3rd 5th 7th 10th and 20th minute
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None