Ignite Creation Date:
2024-05-11 @ 8:31 AM
Last Modification Date:
2024-10-26 @ 3:29 PM
Study NCT ID:
NCT06409520
Status:
RECRUITING
Last Update Posted:
2024-05-10
First Post:
2024-05-07
Brief Title:
Impact Of Subclinical Hypothyroidism On Short-Term Outcomes In Patients With Acute Coronary Syndrome In Sohag University Hospitals
Sponsor:
Sohag University
Organization:
Sohag University
Study Overview
Official Title:
Impact Of Subclinical Hypothyroidism On Short-Term Outcomes In Patients With Acute Coronary Syndrome In Sohag University Hospitals
Status:
RECRUITING
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Introduction
Subclinical hypothyroidism SCH is defined biochemically as a normal serum free thyroxine T4 level in the presence of an increased serum thyroid stimulating hormone TSH concentration1 Its prevalence ranges from 4 to 15 percent and is higher in females and increasing age2 Overt hypothyroidism was associated with accelerated atherosclerosis and an increased risk of cardiovascular abnormalities 3 Some studies have reported a higher atherosclerotic cardiovascular disease risk in patients with SCH 5-8 Elevated TSH levels were observed to be associated with higher cholesterol levels9 Higher mortality was also reported in some studies 610 especially with TSH 100 mIUL in contrast to other studies1112 Heart failure events and myocardial infarction have been reported to be higher1314 These findings in SCH patients could be explained by mitochondrial oxidative stress due to elevated inflammatory markers hypercoagulability endothelial dysfunction insulin resistance increased vascular resistance and left ventricular diastolic and systolic dysfunction31516 As is the case with overt hypothyroidism SCH was observed to be associated with elevated peripheral vascular resistance and diastolic dysfunction17 There are a few studies evaluating the effects of subclinical hypothyroidism on the outcomes of acute coronary syndrome patients
Subclinical hypothyroidism SCH is defined biochemically as a normal serum free thyroxine T4 level in the presence of an increased serum thyroid stimulating hormone TSH concentration1 Its prevalence ranges from 4 to 15 percent and is higher in females and increasing age2 Overt hypothyroidism was associated with accelerated atherosclerosis and an increased risk of cardiovascular abnormalities 3 Some studies have reported a higher atherosclerotic cardiovascular disease risk in patients with SCH 5-8 Elevated TSH levels were observed to be associated with higher cholesterol levels9 Higher mortality was also reported in some studies 610 especially with TSH 100 mIUL in contrast to other studies1112 Heart failure events and myocardial infarction have been reported to be higher1314 These findings in SCH patients could be explained by mitochondrial oxidative stress due to elevated inflammatory markers hypercoagulability endothelial dysfunction insulin resistance increased vascular resistance and left ventricular diastolic and systolic dysfunction31516 As is the case with overt hypothyroidism SCH was observed to be associated with elevated peripheral vascular resistance and diastolic dysfunction17 There are a few studies evaluating the effects of subclinical hypothyroidism on the outcomes of acute coronary syndrome patients
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None