Ignite Creation Date:
2024-05-11 @ 8:31 AM
Last Modification Date:
2024-10-26 @ 3:28 PM
Study NCT ID:
NCT06401720
Status:
ENROLLING_BY_INVITATION
Last Update Posted:
2024-05-07
First Post:
2024-04-26
Brief Title:
Age Related Differences in Respiratory Immune Responses in Influenza Virus Infection
Sponsor:
Karolinska Institutet
Organization:
Karolinska Institutet
Study Overview
Official Title:
Respiratory Immune Responses in Human Influenza Virus Infection Across Age to Understand What Dictates Disease Severity
Status:
ENROLLING_BY_INVITATION
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
NPA-DC
Brief Summary:
The goal of this observational study is to understand immune responses to viral airway infection in adults including the elderly The main questions to answer isare
Why do some individuals acquire only asymptomatic or mild Influenza A virus IAV infection while others become severely ill and even succumb to the same disease
Participants will be asked to donate samples when seeking health care for influenza-like symptoms or if hospitalized for IAV or SARS-CoV-2 Samples asked for are
Blood sample by venepuncture
Blood sample by capillary sampling
Nasopharyngeal aspirate
Nasopharyngeal swab
Endotracheal tube aspirate
Nasal swab
Nasal curette
Breath Explor sampling of expired air
Researchers will compare obtained results with the same type of samples from healthy controls
Why do some individuals acquire only asymptomatic or mild Influenza A virus IAV infection while others become severely ill and even succumb to the same disease
Participants will be asked to donate samples when seeking health care for influenza-like symptoms or if hospitalized for IAV or SARS-CoV-2 Samples asked for are
Blood sample by venepuncture
Blood sample by capillary sampling
Nasopharyngeal aspirate
Nasopharyngeal swab
Endotracheal tube aspirate
Nasal swab
Nasal curette
Breath Explor sampling of expired air
Researchers will compare obtained results with the same type of samples from healthy controls
Detailed Description:
This observational study will specifically investigate different immunological parameters in blood and at the site of infection in patients with IAV symptoms or confirmed infection to understand parameters related to disease course Blood and airway samples will be analyzed for immune cell subsets and their functionality antibodies and other soluble mediators and linked to clinical data Immune cells will be analyzed using multi-color flow cytometry RNA sequencing and in vitro functionality assays Fluids plasma serum supernatants from airway samples and cell culture supernatants will be analyzed using ELISA and or similar methods proximity extension assay Olink etc
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None