Ignite Creation Date:
2024-05-11 @ 8:31 AM
Last Modification Date:
2024-10-26 @ 3:28 PM
Study NCT ID:
NCT06401798
Status:
RECRUITING
Last Update Posted:
2024-06-11
First Post:
2024-05-02
Brief Title:
Locally Delivered Whey Protein Nanoparticles Gel in Stage II Grade B Periodontitis
Sponsor:
Kafrelsheikh University
Organization:
Kafrelsheikh University
Study Overview
Official Title:
Radiographic and Clinical Assessment of Locally Delivered Camel Whey Protein Gel and Camel Whey Protein Nanoparticles Gel in Stage II Grade B Periodontitis Randomized Controlled Clinical Trial
Status:
RECRUITING
Status Verified Date:
2024-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Aim of the current study is to evaluate radiographic and clinical alterations following topical application of CWP gel and CWP nanoparticles gel in stage II grade B periodontitis patients
Detailed Description:
Periodontal disease is an oral inflammatory process that is typically initiated by bacterial infection stimulating the host response to produce various inflammatory mediators in high levels which are also involved in the initiation and progression of periodontal diseaseSuch mediators generate a cascade reaction that eventually leads to the irreversible degradation of connective tissues and bone with subsequent loss of periodontal attachment
A new periodontitis classification scheme has been adopted in which forms of the disease previously recognized as chronic or aggressive are now grouped under a single category periodontitis and are further characterized based on a multi-dimensional staging and grading system Staging is largely dependent upon the severity of disease at presentation as well as on the complexity of disease management while grading provides supplemental information about biological features of the disease including a history-based analysis of the rate of periodontitis progression assessment of the risk for further progression analysis of possible poor outcomes of treatment and assessment of the risk that the disease or its treatment may negatively affect the general health of the patient periodontitis is classified using a system of staging and grading
Staging reflects the severity and extent of disease based on tissue destruction
Stage I Interdental CAL 1-2 mm no tooth loss due to periodontitis maximum probing depth 4 mm with horizontal bone loss mostly
Stage II Interdental CAL 3-4mm no tooth loss due to periodontitis maximum probing depth 5mm with horizontal bone loss mostly
Stage III Interdental CAL 5 mm tooth loss due to periodontitis of 4 dents maximum probing depth 6 mm and mostly associated with vertical bone loss
Stage IV Interdental CAL 5 mm tooth loss due to periodontitis of 5 dents and maximum probing depth 6 mm
Grading of periodontitis refers to how quickly the disease is progressing
Grade A Slow Bone loss is progressing slowly
Grade B Moderate Bone loss is progressing at a moderate rate
Grade C Rapid Bone loss is progressing rapidly The ultimate goal of periodontal therapy is to prevent further disease progression in order to reduce the risk of tooth loss and to restore the tissues that have been lost as a result of periodontitis 4 The gold-standard treatment for periodontitis is subgingival debridement associated with effective supragingival biofilm control However even though mechanical debridement presents favorable short-term results these benefits may not be maintained in the long-term especially in susceptible individuals who develop a chronic hyperinflammatory response against the microbiome that is associated with genetic systemic or environmental factors Failure of periodontal therapy stems largely from an inability to re-verse biofilm dysbiosis and to control inflammation Therefore antimicrobial agents and immune modulators have been considered for the treatment of periodontitis
The additional use of antibiotics systemically in the treatment of periodontitis is limited due to the need for high doses to achieve the appropriate concentration of the drug in the gingival fluid rapidly growing resistance of the bacteria and side effects of the drugs In addition due to the advanced organization of the structure and function of the subgingival biofilm antibiotics may not be effective or can be inactivated Therefore for almost 30 years drug systems antibiotics antiseptics anti-inflamatories and anti-oxidants have been developed in the form of direct subgingival administration The advantage of this form of treatment is the significant concentration of the drug after application and its persistence for up to several weeks With this form of application many side effects that are associated with general systemic therapy can be avoided
Camel whey protein CWP has a potent natural antioxidative effect as it reduces the oxidative stress and strengthens the immune system functions The beneficial effects of CWP dietary supplementation include the stimulation of adaptive and innate immunity and anti-inflammatory antibacterial anticancer antiviral and antioxidative effects In addition it has been shown that CWP improves the treatment of impaired wound healing in diabetic patients Studies have demonstrated the consequences of supplementary CWP on the reduction of inflammatory biomarkers proinflammatory cytokines modulation of the immune functions and free radicals reactive oxygen species Those effects of CWP could play a potential role in treating periodontitis
Local delivery of nanoparticles emerges as a promising strategy for improved treatment These nanoparticles due to their minute size and tailorable properties offer targeted drug delivery to the periodontal pocket This approach concentrates therapeutic effects at the infection site potentially enhancing treatment efficacy while minimizing systemic side effects of conventional medications
Due to technical developments and the availability of cone-beam computed tomography CBCT 3-D imaging has become feasible and offers some advantages and potential for the evaluation of complex anatomical structures CBCT illustrates and validates the possibility of radiographically visualizing and metrically assessing hard and soft periodontal tissues
No previous researches have examined the outcomes of CWP on the treatment of periodontitis Consequently the current study was designed to assess the effects of topical CWP gel and CWP nanoparticle gel as an adjunct to nonsurgical therapy versus nonsurgical therapy alone on the clinical as well as radiographic parameters of stage II grade B periodontitis patients
A new periodontitis classification scheme has been adopted in which forms of the disease previously recognized as chronic or aggressive are now grouped under a single category periodontitis and are further characterized based on a multi-dimensional staging and grading system Staging is largely dependent upon the severity of disease at presentation as well as on the complexity of disease management while grading provides supplemental information about biological features of the disease including a history-based analysis of the rate of periodontitis progression assessment of the risk for further progression analysis of possible poor outcomes of treatment and assessment of the risk that the disease or its treatment may negatively affect the general health of the patient periodontitis is classified using a system of staging and grading
Staging reflects the severity and extent of disease based on tissue destruction
Stage I Interdental CAL 1-2 mm no tooth loss due to periodontitis maximum probing depth 4 mm with horizontal bone loss mostly
Stage II Interdental CAL 3-4mm no tooth loss due to periodontitis maximum probing depth 5mm with horizontal bone loss mostly
Stage III Interdental CAL 5 mm tooth loss due to periodontitis of 4 dents maximum probing depth 6 mm and mostly associated with vertical bone loss
Stage IV Interdental CAL 5 mm tooth loss due to periodontitis of 5 dents and maximum probing depth 6 mm
Grading of periodontitis refers to how quickly the disease is progressing
Grade A Slow Bone loss is progressing slowly
Grade B Moderate Bone loss is progressing at a moderate rate
Grade C Rapid Bone loss is progressing rapidly The ultimate goal of periodontal therapy is to prevent further disease progression in order to reduce the risk of tooth loss and to restore the tissues that have been lost as a result of periodontitis 4 The gold-standard treatment for periodontitis is subgingival debridement associated with effective supragingival biofilm control However even though mechanical debridement presents favorable short-term results these benefits may not be maintained in the long-term especially in susceptible individuals who develop a chronic hyperinflammatory response against the microbiome that is associated with genetic systemic or environmental factors Failure of periodontal therapy stems largely from an inability to re-verse biofilm dysbiosis and to control inflammation Therefore antimicrobial agents and immune modulators have been considered for the treatment of periodontitis
The additional use of antibiotics systemically in the treatment of periodontitis is limited due to the need for high doses to achieve the appropriate concentration of the drug in the gingival fluid rapidly growing resistance of the bacteria and side effects of the drugs In addition due to the advanced organization of the structure and function of the subgingival biofilm antibiotics may not be effective or can be inactivated Therefore for almost 30 years drug systems antibiotics antiseptics anti-inflamatories and anti-oxidants have been developed in the form of direct subgingival administration The advantage of this form of treatment is the significant concentration of the drug after application and its persistence for up to several weeks With this form of application many side effects that are associated with general systemic therapy can be avoided
Camel whey protein CWP has a potent natural antioxidative effect as it reduces the oxidative stress and strengthens the immune system functions The beneficial effects of CWP dietary supplementation include the stimulation of adaptive and innate immunity and anti-inflammatory antibacterial anticancer antiviral and antioxidative effects In addition it has been shown that CWP improves the treatment of impaired wound healing in diabetic patients Studies have demonstrated the consequences of supplementary CWP on the reduction of inflammatory biomarkers proinflammatory cytokines modulation of the immune functions and free radicals reactive oxygen species Those effects of CWP could play a potential role in treating periodontitis
Local delivery of nanoparticles emerges as a promising strategy for improved treatment These nanoparticles due to their minute size and tailorable properties offer targeted drug delivery to the periodontal pocket This approach concentrates therapeutic effects at the infection site potentially enhancing treatment efficacy while minimizing systemic side effects of conventional medications
Due to technical developments and the availability of cone-beam computed tomography CBCT 3-D imaging has become feasible and offers some advantages and potential for the evaluation of complex anatomical structures CBCT illustrates and validates the possibility of radiographically visualizing and metrically assessing hard and soft periodontal tissues
No previous researches have examined the outcomes of CWP on the treatment of periodontitis Consequently the current study was designed to assess the effects of topical CWP gel and CWP nanoparticle gel as an adjunct to nonsurgical therapy versus nonsurgical therapy alone on the clinical as well as radiographic parameters of stage II grade B periodontitis patients
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None