Ignite Creation Date:
2024-05-11 @ 8:31 AM
Last Modification Date:
2024-10-26 @ 3:29 PM
Study NCT ID:
NCT06403176
Status:
COMPLETED
Last Update Posted:
2024-05-07
First Post:
2022-03-14
Brief Title:
Arteriovenous Plasma Multiomics in Patients With Disorders of Consciousness
Sponsor:
First Affiliated Hospital of Zhejiang University
Organization:
First Affiliated Hospital of Zhejiang University
Study Overview
Official Title:
Arteriovenous Plasma Multiomics and Inflammatory Factors in Patients With Disorders of Consciousness
Status:
COMPLETED
Status Verified Date:
2022-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
In order to determine the abnormal cerebral metabolism in the pathological state we compared the blood of internal jugular vein superior vena cava and radial artery during central venous catheterization Metabonomics proteomics and inflammatory factor microarray were used to detect the material differences in arteriovenous blood of patients with disorders of consciousness At the same time we concurrently compared it with the peripheral plasma metabolome of two additional patient cohorts those in-stent restenosis and non-restenosis
Detailed Description:
BackgroundIt is unclear what substances the brain needs to ingest for its activity under pathological conditions
MethodThe uptake and release of substances by the brain were observed by comparing arterial blood with internal jugular vein bloodThe characteristics of brain metabolites were observed by comparing internal jugular vein blood with superior vena cava blood Compared it with the peripheral plasma metabolome of two additional patient cohorts those in-stent restenosis and non-restenosis
ObjectiveBy analyzing different substances this paper briefly describes the pathological mechanism of patients with disorders of consciousness and looks for potential prognostic biomarkers
MethodThe uptake and release of substances by the brain were observed by comparing arterial blood with internal jugular vein bloodThe characteristics of brain metabolites were observed by comparing internal jugular vein blood with superior vena cava blood Compared it with the peripheral plasma metabolome of two additional patient cohorts those in-stent restenosis and non-restenosis
ObjectiveBy analyzing different substances this paper briefly describes the pathological mechanism of patients with disorders of consciousness and looks for potential prognostic biomarkers
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None