Ignite Creation Date:
2024-05-05 @ 7:03 PM
Last Modification Date:
2024-10-26 @ 9:40 AM
Study NCT ID:
NCT00590291
Status:
TERMINATED
Last Update Posted:
2021-05-17
First Post:
2007-12-27
Brief Title:
Molecular Determinants of Coronaruy Artery Disease
Sponsor:
John Barnard
Organization:
The Cleveland Clinic
Study Overview
Official Title:
Genetic Studies of Coronary Artery Disease and Arteriovenous Malformation GeneQuest Molecular Determinants of Coronary Artery Disease
Status:
TERMINATED
Status Verified Date:
2021-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Sequencing completed early
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
GeneQuest
Brief Summary:
The purpose of this study is to discover genes that may cause Coronary Artery Disease CAD or Arteriovenous Malformation AVM
Detailed Description:
The purpose of this study is to discover genes that may cause Coronary Artery Disease CAD or Arteriovenous Malformation AVM Many human diseases are inherited or passed from parent to child in families These diseases occur because of damage to a genes the genetic material that is also called DNA Scientists can now use modern molecular techniques to locate and to find certain genes within the DNA genetic material of a person and to follow their inheritance in a family To find these disease-causing genes requires studies of many affected with the disease and their family members The purpose of this study is to locate and to find the genes for coronary artery disease CAD which occurs when one or more of the arteries that carry oxygen-rich blood from your heart to the rest of your body develop blockages or arteriovenous malformation AVM which causes abnormal vascular connections between arteries and veins particularly near the heart Findings of the genes causing CAD and AVM will have far-reaching effect on the diagnosis treatment and prevention of coronary artery disease and arteriovenous malformation These studies will lead to possible genetic diagnosis early detection of persons at risk for developing CAD or AVM even in the absence of symptoms development of effective drugs more rational and specific therapeutic interventions treatments and ultimately prevention of coronary heart disease Approximately 3-5 years are required to find one human disease gene
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 1R01HL121358 | NIH | Cleveland Clinic IRB | httpsreporternihgovquickSearch1R01HL121358 |
| IRB4333 | OTHER | None | None |