Ignite Creation Date:
2024-05-11 @ 8:30 AM
Last Modification Date:
2024-10-26 @ 3:28 PM
Study NCT ID:
NCT06400056
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-05-06
First Post:
2023-03-18
Brief Title:
Clinical and Laboratory Evaluation of Antifungal Resistance in Tinea Capitis
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
Clinical and Laboratory Evaluation of Antifungal Resistance in Tinea Capitis
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
AIM OF WORK
1 Detect the most common fungal strains that cause tinea capitis
2 Detect Different effectiveness of terbinafine in different cases
3 Detect the resistant strains
4 Detect the mycological and the clinical cure rates upon using systemic terbinafine in treatment of tinea capitis
1 Detect the most common fungal strains that cause tinea capitis
2 Detect Different effectiveness of terbinafine in different cases
3 Detect the resistant strains
4 Detect the mycological and the clinical cure rates upon using systemic terbinafine in treatment of tinea capitis
Detailed Description:
Introduction
Tinea capitis is a superficial fungal infection of the skin of the scalp with a propensity for attacking hair shafts and follicles The disease is considered to be a form of superficial mycosis or dermatophytosis
It may affect all or part of the childs scalp
Mold-like fungi called dermatophytes cause tinea capitis It is caused primarily by Dermatophyte species Microsporm and trichopyton In Egypt dermatophytes called Microsporum canis and Microsporum audouinii are the most common causes of the infection Fungi thrive in warm moist environments It commonly grows in tropical places
Tinea capitis can be divided into inflammatory and non-inflammatory types the non-inflammatory type usuallywill not be complicated by scaring alopecia the inflammatory type may result in Kerion a painful nodule with pus and scaring alopecia The clinical manifestations of tinea capitis are classified as endothrix ectothrix or favus In the endothrix form hyphae grow down the follicle and penetrate the hair shaft then grow completely within the hair shaft This form is caused predominantly by T tonsurans and T violaceum In the ectothrix form the hyphae invade the hair shaft at mid follicle Afterwards hyphae grow out of the follicle covering the hair surface This form is caused by M canis M audouinii Microsporum ferrugineum and Trichophyton verrucosum The hyphae grow parallel to the hair shaft in favus form then degenerate leaving long tunnels within the hair shaft Favus form is caused by Trichophyton schoenleinii and is characterized by yellow crust around the hair shafts and can result in permanent scarring alopecia
Tinea capitis also spreads very easily The patients can catch the infection from contact with infected people animals and soil They can also get it by using objects and touching surfaces that harbor the fungus Tinea capitis can live for a long time on infected objects and surfaces It is very contagious and can spread quickly among children
The diagnosis is suspected primarily clinically based on the appearance of the scalp lesion A Woods lamp test performed to confirm the presence of a fungal scalp infection Dermoscopy is a useful and non invasive diagnostic tool which aids in the diagnosis of tinea capitis the diagnosis can be confirmed by microscopic examination of KOH
Fungal culture is the gold standard to diagnose dermatophytosis
fungal culture can help to differentiate fungal species
The treatment of tinea capitis requires systemic antifungal therapy because topical antifungal agents cannot penetrate the hair shaft sufficiently to eradicate infection Griseofulvin the former gold standard agent has been associated with treatment failure a retrospective review of patients medical records revealed a failure rate of 393 in octobr 2007 The FDA has approved terbinafine oral granules Lamisil which can be sprinkled on food for tinia capitis in children four years and older fluconazole and Itraconazole also used in treatment of Tinea capitis although they are not FDA approved
In the past few years Numerous cases of tinea capitis that was initially resistant to systemic antifungal or recurred rapidly after a brief interval improvement recently have been seen
In general clinical resistance is considered to be the persistence or progression of an infection despite appropriate antimicrobial therapy This resistance can be attributed to a combination of factors related to the host the antifungal agent or the pathogen
Tinea capitis is a superficial fungal infection of the skin of the scalp with a propensity for attacking hair shafts and follicles The disease is considered to be a form of superficial mycosis or dermatophytosis
It may affect all or part of the childs scalp
Mold-like fungi called dermatophytes cause tinea capitis It is caused primarily by Dermatophyte species Microsporm and trichopyton In Egypt dermatophytes called Microsporum canis and Microsporum audouinii are the most common causes of the infection Fungi thrive in warm moist environments It commonly grows in tropical places
Tinea capitis can be divided into inflammatory and non-inflammatory types the non-inflammatory type usuallywill not be complicated by scaring alopecia the inflammatory type may result in Kerion a painful nodule with pus and scaring alopecia The clinical manifestations of tinea capitis are classified as endothrix ectothrix or favus In the endothrix form hyphae grow down the follicle and penetrate the hair shaft then grow completely within the hair shaft This form is caused predominantly by T tonsurans and T violaceum In the ectothrix form the hyphae invade the hair shaft at mid follicle Afterwards hyphae grow out of the follicle covering the hair surface This form is caused by M canis M audouinii Microsporum ferrugineum and Trichophyton verrucosum The hyphae grow parallel to the hair shaft in favus form then degenerate leaving long tunnels within the hair shaft Favus form is caused by Trichophyton schoenleinii and is characterized by yellow crust around the hair shafts and can result in permanent scarring alopecia
Tinea capitis also spreads very easily The patients can catch the infection from contact with infected people animals and soil They can also get it by using objects and touching surfaces that harbor the fungus Tinea capitis can live for a long time on infected objects and surfaces It is very contagious and can spread quickly among children
The diagnosis is suspected primarily clinically based on the appearance of the scalp lesion A Woods lamp test performed to confirm the presence of a fungal scalp infection Dermoscopy is a useful and non invasive diagnostic tool which aids in the diagnosis of tinea capitis the diagnosis can be confirmed by microscopic examination of KOH
Fungal culture is the gold standard to diagnose dermatophytosis
fungal culture can help to differentiate fungal species
The treatment of tinea capitis requires systemic antifungal therapy because topical antifungal agents cannot penetrate the hair shaft sufficiently to eradicate infection Griseofulvin the former gold standard agent has been associated with treatment failure a retrospective review of patients medical records revealed a failure rate of 393 in octobr 2007 The FDA has approved terbinafine oral granules Lamisil which can be sprinkled on food for tinia capitis in children four years and older fluconazole and Itraconazole also used in treatment of Tinea capitis although they are not FDA approved
In the past few years Numerous cases of tinea capitis that was initially resistant to systemic antifungal or recurred rapidly after a brief interval improvement recently have been seen
In general clinical resistance is considered to be the persistence or progression of an infection despite appropriate antimicrobial therapy This resistance can be attributed to a combination of factors related to the host the antifungal agent or the pathogen
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
False
Is an FDA AA801 Violation?:
None