Ignite Creation Date:
2024-05-11 @ 8:30 AM
Last Modification Date:
2024-10-26 @ 3:28 PM
Study NCT ID:
NCT06402175
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-06-05
First Post:
2024-04-20
Brief Title:
Characteristics and Outcomes of Patients With Hematological Malignancies
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
Characteristics and Outcomes of Patients With Hematological Malignancies at Main Assuit University Hospital A Single Centre Study
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The pattern of hematological malignancies HMs in developing countries and developed countries differs Among the different types of cancers leukemia lymphoma and multiple myeloma appear to have greatly increased in frequency
Detailed Description:
The pattern of hematological malignancies HMs in developing countries and developed countries differs Among the different types of cancers leukemia lymphoma and multiple myeloma appear to have greatly increased in frequency These malignancies are induced by genetic damage or mutation in somatic cells which can result from environmental exposure to chemicals ionizing radiation and viral agents Comparison of the incidence of HMs across geographic regions and time is complicated by the existence of different disease classification systems and diagnostic criteria that vary by country and even between hospitals and cancer registries CRs within a country
Leukemia is a malignant neoplasm of hematopoietic stem cells characterized by diffuse replacement of bone marrow or peripheral blood by neoplastic cells its etiology is obscure Leukemia typing is based on how quickly the disease develops and progresses Leukemia is either chronic or acute Furthermore leukemia typing is also based on the type of white blood cell that is affected There are 4 common types of leukemia acute myeloid leukemia AML acute lymphoblastic leukemia ALL chronic myeloid leukemia CML and chronic lymphocytic leukemia CLL Most acute leukemias are classified as lymphoid or myeloid lineages via standard microscopic morphology cytochemistry and immunophenotyping Previous studies have shown that there are important differences in the incidence of the various leukemia subtypes according to geography raceethnicity age and trend pattern indicating that the subtypes may have different etiological factors and that comprehensive global assessment of leukemia patterns is warranted
Lymphomas are a heterogenous group of diseases with differences in epidemiology histology and prognosis The incidence of Hodgkins lymphoma HL and nonHodgkins lymphoma NHL is higher among males than females
Multiple myeloma MM is included in the spectrum of diseases ranging from monoclonal gammopathy of unknown significance MGUS to plasma cell leukemia Plasma cell proliferation usually results in extensive skeletal destruction with osteolytic lesions hypercalcemia anemia and occasionally plasma cell infiltration in different organs Excessive production of a monoclonal M protein can lead to renal failure hyperviscosity syndrome or recurrent bacterial infections
Leukemia is a malignant neoplasm of hematopoietic stem cells characterized by diffuse replacement of bone marrow or peripheral blood by neoplastic cells its etiology is obscure Leukemia typing is based on how quickly the disease develops and progresses Leukemia is either chronic or acute Furthermore leukemia typing is also based on the type of white blood cell that is affected There are 4 common types of leukemia acute myeloid leukemia AML acute lymphoblastic leukemia ALL chronic myeloid leukemia CML and chronic lymphocytic leukemia CLL Most acute leukemias are classified as lymphoid or myeloid lineages via standard microscopic morphology cytochemistry and immunophenotyping Previous studies have shown that there are important differences in the incidence of the various leukemia subtypes according to geography raceethnicity age and trend pattern indicating that the subtypes may have different etiological factors and that comprehensive global assessment of leukemia patterns is warranted
Lymphomas are a heterogenous group of diseases with differences in epidemiology histology and prognosis The incidence of Hodgkins lymphoma HL and nonHodgkins lymphoma NHL is higher among males than females
Multiple myeloma MM is included in the spectrum of diseases ranging from monoclonal gammopathy of unknown significance MGUS to plasma cell leukemia Plasma cell proliferation usually results in extensive skeletal destruction with osteolytic lesions hypercalcemia anemia and occasionally plasma cell infiltration in different organs Excessive production of a monoclonal M protein can lead to renal failure hyperviscosity syndrome or recurrent bacterial infections
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None