Ignite Creation Date:
2024-05-11 @ 8:30 AM
Last Modification Date:
2024-10-26 @ 3:29 PM
Study NCT ID:
NCT06404242
Status:
RECRUITING
Last Update Posted:
2024-05-08
First Post:
2024-04-29
Brief Title:
Plaque Characteristics Predict Recurrent Stroke in MCA Stroke Patients
Sponsor:
University Medical Center Ho Chi Minh City UMC
Organization:
University Medical Center Ho Chi Minh City UMC
Study Overview
Official Title:
Plaque Characteristics From Vessel Wall Magnetic Resonance Imaging Predict Recurrent Stroke in Ischemic Stroke Patients Due to Middle Cerebral Artery Stenosis
Status:
RECRUITING
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The epidemiology of TOAST classification in Asian patients seems to differ due to the higher rates of large-artery atherosclerosis The complex pathology of atherosclerosis could lead to recurrent stroke including shear stress on the endothelium disturbance of the flow occlusion at the origin of the perforating artery and other complications plaque inflammation plaque hemorrhage plaque rupture that could lead to stroke and recurrent stroke Therefore The exact determination of the etiology of stroke due to atherosclerosis is the most critical factor for treatment and prognostic On the other hand HR-MRI could be a useful imaging modality to evaluate the characteristics of plaque in stroke patients due to atherosclerosis stenosis which will help us find out the etiology of stroke Previous studies have demonstrated its prognosis value in predicting recurrent stroke in the same vascular territory The investigators hypothesize that with an appropriate evaluation HR-MRI could help to predict recurrent stroke in the same vascular territory in patients with high-risk plaque characteristics on HR-MRI These findings could contribute to individual treatment according to etiology
The investigators intend to conduct a study to determine the correlation between plaque characteristics and recurrent stroke in the same vascular territory in ischemic stroke patients due to middle cerebral artery stenosis
The investigators intend to conduct a study to determine the correlation between plaque characteristics and recurrent stroke in the same vascular territory in ischemic stroke patients due to middle cerebral artery stenosis
Detailed Description:
The epidemiology of TOAST classification in Asian patients seems to differ due to the higher rates of large-artery atherosclerosis 1 The complex pathology of atherosclerosis could lead to recurrent stroke including shear stress on the endothelium disturbance of the flow occlusion at the origin of the perforating artery and other complications plaque inflammation plaque hemorrhage plaque rupture that could lead to stroke and recurrent stroke 2 Therefore The exact determination of the etiology of stroke due to atherosclerosis is the most critical factor for treatment and prognostic On the other hand HR-MRI could be a useful imaging modality to evaluate the characteristics of plaque in stroke patients due to atherosclerosis stenosis which will help us find out the etiology of stroke 3 Previous studies have demonstrated its prognosis value in predicting recurrent stroke in the same vascular territory 4 The investigators hypothesize that with an appropriate evaluation HR-MRI could help to predict recurrent stroke in the same vascular territory in patients with high-risk plaque characteristics on HR-MRI These findings could contribute to individual treatment according to etiology 56
The investigators intend to conduct a study to determine the correlation between plaque characteristics and recurrent stroke in the same vascular territory in ischemic stroke patients due to middle cerebral artery stenosis
The investigators intend to conduct a study to determine the correlation between plaque characteristics and recurrent stroke in the same vascular territory in ischemic stroke patients due to middle cerebral artery stenosis
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None