Ignite Creation Date:
2024-05-11 @ 8:30 AM
Last Modification Date:
2024-10-26 @ 3:28 PM
Study NCT ID:
NCT06400082
Status:
ACTIVE_NOT_RECRUITING
Last Update Posted:
2024-05-06
First Post:
2024-04-26
Brief Title:
Topical Insulin for Postoperative Wound Healing
Sponsor:
Cairo University
Organization:
Cairo University
Study Overview
Official Title:
Investigating the Impact of Topical Insulin on Postoperative Wound Healing in Diabetic and Non-Diabetic Patients A Randomized Controlled Trial
Status:
ACTIVE_NOT_RECRUITING
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study aimed to investigate the potential effect of applying topical insulin therapy on the management and healing of postoperative wounds in patients known with type 2 diabetes mellitus T2DM and in a parallel group without diabetes Investigators also studied the effect of topical insulin therapy on the expression of e-cadherin and Ki67 as markers for cellular proliferation and wound repair The levels of IL-6 and the H2O2-induced DNA damage product 8-hydroxy-2-deoxyguanosine 8-OHdG were assessed as markers for inflammation and oxidative stress Finally histomorphological assessment of skin biopsies was also carried out
Detailed Description:
The study participants will be recruited from general surgery department all patients with elective surgical procedure who will be admitted at the department for at least one week as it is the minimal duration of postoperative wound healing and the study will be conducted according to the regulations of ethical committee of clinical studies in the Faculty of Medicine Cairo University
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None