Ignite Creation Date:
2024-05-11 @ 8:30 AM
Last Modification Date:
2024-10-26 @ 3:29 PM
Study NCT ID:
NCT06409416
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-06-18
First Post:
2024-05-07
Brief Title:
Tumor Cell Plasticity and Aggressiveness in Human Non-small Cell Lung Cancer
Sponsor:
Casa Sollievo della Sofferenza IRCCS
Organization:
Casa Sollievo della Sofferenza IRCCS
Study Overview
Official Title:
Identification of Molecular Mechanisms Which Drive Tumor Cell Plasticity and Aggressiveness in Human Non-small Cell Lung Cancer
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Tumor cell plasticity TCP is a conubium of processes which lead to re-activation of developmental programs correlating with epithelial-to-mesenchymal transition and ultimately leading to acquisition of stem cell properties and transdifferentiation potential Little is known about the molecular mechanisms governing TCP in lung adenocarcinoma LUAD ie the most frequent lung cancer subtype The investigators recently identified prognostic 7-miRNAs10-mRNAs signatures which accurately identified aggressive LUAD among patients with early-stage disease Stage I Furthermore the investigators showed that such tumors show TCP features ie mesenchymal and stem-cell traits high-metastatic potential Here the investigators aim to explore by RNAseq and by immunophenotyping at a single-cell level scRNAseqAbSeq the molecular features of aggressive LUAD to unveil the mechanisms triggering TCP The investigators predict thier results will be relevant for the development of more effective therapeutic protocols for management of aggressive LUAD
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None