Ignite Creation Date:
2024-05-11 @ 8:30 AM
Last Modification Date:
2024-10-26 @ 3:28 PM
Study NCT ID:
NCT06402305
Status:
RECRUITING
Last Update Posted:
2024-05-07
First Post:
2024-05-02
Brief Title:
Lipid Profile and Ultrasound Findings in Patients With Pancreaticobiliary Diseases
Sponsor:
Alaa Mohamed Mostafa
Organization:
Sohag University
Study Overview
Official Title:
Lipid Profile and Ultrasound Findings in Patients With Pancreaticobiliary Diseases
Status:
RECRUITING
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Gall stones happen is the most prevalent pathology affecting the biliary system due to its Physiological function of concentration of bile having a prevalence of 10-15 and an incidence of 14 per year in the adult population of developed countries Halldestam et al 2009 Women are more commonly affected by gall stone disease as compared to men Attili et al 1995
Multiple risk factors responsible for the Gall stone formation include modifiable factors such as lifestyle factors reduced physical activity rapid weight loss fasting and oral contraceptives Di Ciaula et al 2013 dietary factors high fat high cholesterol high refined carbohydrates and low fiber metabolic syndrome obesity diabetes mellitus dyslipidemia and hyperinsulinemia Cuevas et al 2004
Among all the above mentioned risk factors serum lipids are considered to be the most important risk factor involved in the pathogenesis of Gall stone disease Celika et al 2015 Hyperlipidemia is generally characterized by high serum levels of total cholesterol triglycerides low density lipoproteins LDL-C and low levels of high-density lipoprotein HDL-C Some studies have showed a significant association of hyperlipidemia with gall stones especially hypertriglyceridemia and increased LDL-C levels Rao et al 2012
Acute pancreatitis AP is an inflammatory condition of the pancreas that originates within the pancreatic acinar cells and causes pancreatic necrosis systemic inflammatory response syndrome and multiple organ failure Crockett et al 2013 According to The revised Atlanta classification system from 2012 AP is diagnosed on the basis of two of three criteria-typically belt-like abdominal pain an elevated serum lipase level three times above the normal threshold and radiological imaging signs of pancreatitis Parniczky et al2016
Severe hypertriglyceridemia is a well-known cause of AP Recent studies have suggested that elevated serum triglyceride and low high-density lipoprotein cholesterol HDL-C levels are associated with persistent organ failure in acute pancreatitis Peng et al 2015 With the change of peoples diet structure and lifestyle the incidence and mortality of hypertriglyceridemic AP are increasing year by year and has surpassed alcohol as the second leading cause of AP Carr et al 2016
Chronic pancreatitis is a syndrome characterized by chronic progressive pancreatic inflammation fibrosis and scarring resulting in damage to and loss of exocrine acinar endocrine islet cells and ductal cellsMajumder S 2016
Multiple risk factors responsible for the Gall stone formation include modifiable factors such as lifestyle factors reduced physical activity rapid weight loss fasting and oral contraceptives Di Ciaula et al 2013 dietary factors high fat high cholesterol high refined carbohydrates and low fiber metabolic syndrome obesity diabetes mellitus dyslipidemia and hyperinsulinemia Cuevas et al 2004
Among all the above mentioned risk factors serum lipids are considered to be the most important risk factor involved in the pathogenesis of Gall stone disease Celika et al 2015 Hyperlipidemia is generally characterized by high serum levels of total cholesterol triglycerides low density lipoproteins LDL-C and low levels of high-density lipoprotein HDL-C Some studies have showed a significant association of hyperlipidemia with gall stones especially hypertriglyceridemia and increased LDL-C levels Rao et al 2012
Acute pancreatitis AP is an inflammatory condition of the pancreas that originates within the pancreatic acinar cells and causes pancreatic necrosis systemic inflammatory response syndrome and multiple organ failure Crockett et al 2013 According to The revised Atlanta classification system from 2012 AP is diagnosed on the basis of two of three criteria-typically belt-like abdominal pain an elevated serum lipase level three times above the normal threshold and radiological imaging signs of pancreatitis Parniczky et al2016
Severe hypertriglyceridemia is a well-known cause of AP Recent studies have suggested that elevated serum triglyceride and low high-density lipoprotein cholesterol HDL-C levels are associated with persistent organ failure in acute pancreatitis Peng et al 2015 With the change of peoples diet structure and lifestyle the incidence and mortality of hypertriglyceridemic AP are increasing year by year and has surpassed alcohol as the second leading cause of AP Carr et al 2016
Chronic pancreatitis is a syndrome characterized by chronic progressive pancreatic inflammation fibrosis and scarring resulting in damage to and loss of exocrine acinar endocrine islet cells and ductal cellsMajumder S 2016
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None