Ignite Creation Date:
2024-05-11 @ 8:30 AM
Last Modification Date:
2024-10-26 @ 3:29 PM
Study NCT ID:
NCT06405815
Status:
COMPLETED
Last Update Posted:
2024-05-09
First Post:
2024-05-04
Brief Title:
A Radiomic Model for Risk of Local Recurrence and DFS for T3 and T4 Non-small Cell Lung Cancer
Sponsor:
Jinling Hospital China
Organization:
Jinling Hospital China
Study Overview
Official Title:
Development of a Tumor and Peritumor Radiomics-based Model to Predict the High-risk Surgical Margin and Prognosis of T3 and T4 Non-Small Cell Lung Cancer
Status:
COMPLETED
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The investigators retrospectively collected the participants with T3 and T4 N0-2 M0 NSCLC patients resected between January 2013 to December 2021 for training and internal validation The Clinical data preoperative laboratory results and images were collected High-risk margins were defined as R1 or R2 surgical margins or local recurrence during follow-up and the investigators also collected the disease-free survival time On the Deepwise multi-modal research platform the images were semi-automatically segmented and expanded outward by 3mm to obtain the peritumor tissue PyRadiomics was used to extract the radiomic features LASSO was used to select the features and tumor radiomics model peritumor model and combined model were built using 5-fold cross-validation And it was further tested on the independent cohort Discrimination was assessed by using the C-index and area under the receiver operating characteristic curve AUC sensibility specificity
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None