Ignite Creation Date:
2024-05-11 @ 8:29 AM
Last Modification Date:
2024-10-26 @ 3:28 PM
Study NCT ID:
NCT06399796
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-05-06
First Post:
2024-05-01
Brief Title:
Insulin Resistance in Relation to Hyperthyroidism and Hypothyroidism
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
Insulin Resistance in Relation to Hyperthyroidism and Hypothyroidism
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Insulin resistance and its relation to hyperthyrodism and Hypothyroidism
Detailed Description:
Thyroid hormones TH play an important role in regulating energy balance metabolism of glucose and lipids While TH oppose the action of insulin and stimulate the hepatic gluconeogenesis and glycogenolysis they up-regulate the expression of genes such as glucose transporter type-4 GLUT--4 and phosphoglycerate kinase involved in glucose transport and glycolysis respectively thus acting synergistically with insulin facilitating glucose disposal and utilization in peripheral tissues
This indicates a possible interplay between thyroid status and insulin sensitivity Homeostatic model assessment HOMA is a method for assessing β-cell function and insulin resistance IR from basal fasting glucose and insulin or C-peptide concentrations The homeostasis model assessment HOMA for IR HOMA-IR derives estimates of insulin sensitivity from the mathematical modeling of fasting plasma glucose and insulin concentrations
Homeostatic model assessment for insulin resistance HOMA - IR based on fasting glucose and insulin measurements derived from the product of the insulin and glucose values divided by a constant that is calculated by using the following formula fasting glucose mgdL X fasting insulin mUL 405 for SI units fasting glucose mmolL X fasting insulin mUL 225 a value greater than 2 indicates insulin resistance
In both hyper- as well as hypothyroid groups there was significant increase in LDL levels The amount of insulin specifically bound and the number of insulin receptors per cell were inversely correlated with the LDL level The number of insulin receptors and the amount of insulin bound in the tested subjects with increased LDL were correspondingly low
This indicates a possible interplay between thyroid status and insulin sensitivity Homeostatic model assessment HOMA is a method for assessing β-cell function and insulin resistance IR from basal fasting glucose and insulin or C-peptide concentrations The homeostasis model assessment HOMA for IR HOMA-IR derives estimates of insulin sensitivity from the mathematical modeling of fasting plasma glucose and insulin concentrations
Homeostatic model assessment for insulin resistance HOMA - IR based on fasting glucose and insulin measurements derived from the product of the insulin and glucose values divided by a constant that is calculated by using the following formula fasting glucose mgdL X fasting insulin mUL 405 for SI units fasting glucose mmolL X fasting insulin mUL 225 a value greater than 2 indicates insulin resistance
In both hyper- as well as hypothyroid groups there was significant increase in LDL levels The amount of insulin specifically bound and the number of insulin receptors per cell were inversely correlated with the LDL level The number of insulin receptors and the amount of insulin bound in the tested subjects with increased LDL were correspondingly low
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None