Ignite Creation Date:
2024-05-11 @ 8:28 AM
Last Modification Date:
2024-10-26 @ 3:28 PM
Study NCT ID:
NCT06399770
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-05-06
First Post:
2024-05-01
Brief Title:
The Role of Muscle Ultrasound in Assessment of Sample of Patients With Limb-girdle Muscular Dystrophy
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
The Role of Muscle Ultrasound in Assessment of Sample of Patients With Limb-girdle Muscular Dystrophy
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
1 to detect the characteristic patterns of muscle involvement in suspected cases of LGMD using muscle ultrasound
2 to use the muscle ultrasound findings clinically categorized the different types of LGMD
3 to correlate the muscle ultrasound findings with the findings of the other assissed scales
2 to use the muscle ultrasound findings clinically categorized the different types of LGMD
3 to correlate the muscle ultrasound findings with the findings of the other assissed scales
Detailed Description:
Limb-girdle muscular dystrophies LGMD are muscular dystrophies that affect skeletal muscles mostly proximal hips and shoulder muscles They are caused by a mutation in a gene encoding a protein which is specific to each subtype LGMD inheritance is either autosomal dominant or recessive Several types of LGMD were described depending on the causative mutations 1 LGMD is one of inherited myopathies that characterized by selective involvement of muscles Selectivity is a sign of muscle diseases and helps direct the diagnosis however it cannot always be identified clinically consequently the importance of using muscle MRI and ultrasound are to detect this selectivity and aid in the diagnosis 2 Ultrasound with a high resolution enables viewing of the muscle nerve and nearby structures and can provide real-time information in neuromuscular illnesses 3 Muscle Ultrasound MUS can detect the same patterns of muscle affection as MRI 4 In addition it is safe accessible low-cost and free of ionizing radiation with no known contraindications and no difficulties associated with MRI such as claustrophobia metallic implants and the requirement for sedation in children hence it can be used as a supplemental technique to electro- diagnosis 5 Ultrasound can provide real-time information related to muscle activation and movement patterns so selective substitution of muscle ultrasound for MRI can result in significant cost-saving for the health care system 6 However its primary drawback is that it is operator-dependent and has a limited ability to image deeper structures 7 According to studies MUS can provide a key provisional probable diagnosis especially when genetic diagnosis is not accessible or expensive or to provide guide to the proper genetic testing when it is available 2 8 In limb girdle pattern of weakness patients MUS assisted diagnose quadriceps sparing myopathy selective affection of one head of gastrocnemius as medial head and soleus more than lateral head in FKRP LGMD2I and calpain-3 deficiency LGMD2A and selective affection of lateral head as in LGMD2B
dysferlin 9 MUS can also help diagnose the treatable types of limb girdle myopathies like POPME by recognizing specific muscle involvement patterns 2 Few research 10 utilized the MUS to detect suspected LGMD and none compared the MUS findings with those of the different psychometric measures The present study aims to we aimed to evaluate the role of MUS in the assessment of patients with suspected LGMD to identify characteristic patterns these of muscle involvement in suspected cases of LGMD and to correlate changes with findings of the different psychometric scales
dysferlin 9 MUS can also help diagnose the treatable types of limb girdle myopathies like POPME by recognizing specific muscle involvement patterns 2 Few research 10 utilized the MUS to detect suspected LGMD and none compared the MUS findings with those of the different psychometric measures The present study aims to we aimed to evaluate the role of MUS in the assessment of patients with suspected LGMD to identify characteristic patterns these of muscle involvement in suspected cases of LGMD and to correlate changes with findings of the different psychometric scales
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None